Increased plasminogen activator activity and plasminogen activator inhibition in spermatozoa and seminal plasma of the ram after serum gonadotrophin (PMSG) administration. Correlation with the increased level of testosterone in the blood
| Autor: | Ioannis Taitzoglou, N. Kokolis, C. Rekkas, S. Belibasaki, A. Smokovitis |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Gonadotropins Equine medicine.drug_class Plasmin Urology Semen Plasminogen Activators Endocrinology Human fertilization Reference Values Internal medicine medicine Animals Testosterone Sheep biology General Medicine biochemical phenomena metabolism and nutrition Spermatozoa Sperm Plasminogen Inactivators Enzyme inhibitor Tissue Plasminogen Activator biology.protein Gonadotropin Plasminogen activator medicine.drug |
| Zdroj: | Andrologia. 23:273-278 |
| ISSN: | 1439-0272 0303-4569 |
| DOI: | 10.1111/j.1439-0272.1991.tb02559.x |
| Popis: | After a single injection of serum gonadotrophin (PMSG) at the dose of 15 IU/kg, i.m. into rams testosterone in the plasma of blood showed a significant rise between 4th and 7th day post-injection. At the same time (4th-7th day) the plasminogen activator activity (PAA) in seminal plasma was found to be increased, but the plasminogen activator inhibition (PAI) expressed against t-PA (anti-t-PA) showed an increase between 32nd and 46th day. In spermatozoa a marked increase of PAA was revealed between 32nd and 46th day post-injection, while an increase of PAI (anti-t-PA) was exhibited on the 74th day. Plasmin inhibition (PI) in seminal plasma and spermatozoa showed no change compared to controls. A positive correlation has been found between increased concentrations of testosterone and PAA or PAI (anti-t-PA) in spermatozoa and seminal plasma. The induced increase of PAA in spermatozoa under the effect of testosterone might be of physiological importance, since PAA is localized to sperm membranes and might participate in the whole process of fertilization. |
| Databáze: | OpenAIRE |
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