Craniomaxillofacial osteosarcoma:the role of surgical margins

Autor: Tom Böhling, Antti Mäkitie, Karri Mesimäki, Risto Kontio, Paula Lindholm, Peppi Koivunen, Mika Sampo, Kauko Saarilahti, Jaana Hagström
Přispěvatelé: Department of Oral and Maxillofacial Diseases, HUS Head and Neck Center, Oral and Maxillofacial Surgery, Medicum, Department of Pathology, Tom Böhling / Principal Investigator, Department of Oncology, HUS Comprehensive Cancer Center, Department of Ophthalmology and Otorhinolaryngology, Korva-, nenä- ja kurkkutautien klinikka, HUSLAB
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Maxillofacial
Survival
medicine.medical_treatment
Postoperative radiotherapy
CRANIOFACIAL OSTEOSARCOMA
head and neck
surgery
0302 clinical medicine
PROGNOSTIC-FACTORS
Finland
NECK REGION
Curative intent
Osteosarcoma
Margins of Excision
JAWS
Middle Aged
3. Good health
Treatment Outcome
Curative treatment
030220 oncology & carcinogenesis
Oral Surgery
Adult
medicine.medical_specialty
Adolescent
Bone Neoplasms
Maxillary Bones
survival
03 medical and health sciences
Young Adult
Head and neck
medicine
Humans
HEAD
Radical surgery
maxillofacial
radiotherapy
Aged
Retrospective Studies
Radiotherapy
business.industry
Mean age
030206 dentistry
medicine.disease
3126 Surgery
anesthesiology
intensive care
radiology
313 Dentistry
Surgery
Radiation therapy
Otorhinolaryngology
EXPERIENCE
Neoplasm Recurrence
Local
business
OSTEOGENIC-SARCOMA
Popis: Background: Osteosarcomas (OS) in the craniomaxillofacial (CMF) region are typically diagnosed at later age than long-bone OS, but they are reported to have better 5-year survival. Curative treatment warrants wide surgical resection, which is often not possible in the CMF region. The purpose of this article is to present a nationwide series of CMF in Finland to discuss the role of surgery. Patients and methods: All 21 CMF OS patients managed in Finland from 1992 to 2009 were included. The mean age was 40 years (range 15e72). Data on patient and tumor characteristics, treatment modalities, and survival were recorded. All patients had a minimum follow-up of 5 years or until death. Results: OS was evenly represented in the mandible and maxillary bones, which together constituted 76% of all sites. Surgery with curative intent was carried out in 20 patients. Clear margins were achieved in only five cases. Eight (40%) of these 20 patients died due to OS, and their average survival time was 1.3 years. Seven (35%) out of the 20 patients received radiotherapy due to close/intralesional surgical margins, and four of them did not develop recurrences during the follow-up. Conclusions: The results suggest that postoperative radiotherapy may alter the prognosis in CMF OS, particularly in cases with close or intralesional margins. This may increase the survival rates achieved by prompt action in performing radical surgery. (C) 2019 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
Databáze: OpenAIRE
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