Buspirone metabolite structure profile using a standard liquid chromatographic-mass spectrometric protocol
| Autor: | Mike S. Lee, Kevin J. Volk, Edward H. Kerns, Robyn A. Rourick |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Chromatography Molecular mass Metabolite Chemical structure General Chemistry Decane Mass spectrometry High-performance liquid chromatography Buspirone Mass Spectrometry Body Fluids Rats Rats Sprague-Dawley chemistry.chemical_compound Anti-Anxiety Agents chemistry medicine Animals Glucuronide Chromatography High Pressure Liquid medicine.drug |
| Zdroj: | Journal of Chromatography B: Biomedical Sciences and Applications. 698:133-145 |
| ISSN: | 0378-4347 |
| Popis: | A rapid and systematic LC-MS protocol is utilized to profile buspirone metabolites. Analysis of rat bile, urine and liver S9 samples using a standard LC-MS method provides structural information for 25 metabolites. The resulting buspirone metabolite structure database contains characteristic retention time, molecular mass and MS-MS product ion information for each compound. Metabolites are categorized according to profile groups, which illustrate that substitution reactions are primarily associated with the azaspirone decane dione and pyrimidine substructures. Structures of new buspirone metabolites are reported and include the despyrimidinyl, despyrimidinylpiperazine, glucuronide, hydroxyglucuronide (four isomers), methoxyglucuronide and hydroxymethoxyglucuronide (two isomers) buspirone metabolites. |
| Databáze: | OpenAIRE |
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