Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

Autor:	Jerome I. Rotter, Elaine R. Nimmo, Jeffrey C. Barrett, Jacques Belaiche, Cynthia Sandor, Martine De Vos, Natalie J. Prescott, Mark J. Daly, André Van Gossum, Dan L. Nicolae, Alain Bitton, A. Hillary Steinhart, Christopher G. Mathew, Rhian Gwilliam, L. Philip Schumm, M. Michael Barmada, Panos Deloukas, Olivier Dewit, Severine Vermeire, Debby Laukens, Miguel Regueiro, Edouard Louis, Kent D. Taylor, Cécile Libioulle, Jonathan Marchini, Carl A. Anderson, Emily O. Kistner, Judy H. Cho, John D. Rioux, Simon Heath, Clive M. Onnie, Themistocles Dassopoulos, John C. Mansfield, Myriam Mni, Jack Satsangi, Mark Tremelling, Jean-Pierre Hugot, Hazel E. Drummond, Ramnik J. Xavier, Mark Lathrop, Michel Georges, Steven R. Brant, Lon R. Cardon, Miles Parkes, Jilur Ghori, Tariq Ahmad, Michael T. Murtha, Mark S. Silverberg, Stephan R. Targan, Suzannah Bumpstead, Ivo Gut, Todd Green, Derek P. Jewell, Richard H. Duerr, Denis Franchimont, Paul Rutgeerts, Anne M. Griffiths, Sarah Hansoul, Diana Zelenika, Sheila A. Fisher, Lisa W. Datta
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	Genetics education.field_of_study Genome Human Population Quantitative Trait Loci Locus (genetics) Genome-wide association study Disease Biology Crohn Disease IRGM Humans Genetic Predisposition to Disease education ATG16L1 CDKAL1 Genetic association
Zdroj:	Barrett, J C, Hansoul, S, Nicolae, D L, Cho, J H, Duerr, R H, Rioux, J D, Brant, S R, Silverberg, M S, Taylor, K D, Barmada, M M, Bitton, A, Dassopoulos, T, Datta, L W, Green, T, Griffiths, A M, Kistner, E O, Murtha, M T, Regueiro, M D, Rotter, J I, Schumm, L P, Steinhart, A H, Targan, S R, Xavier, R J, Libioulle, C, Sandor, C, Lathrop, M, Belaiche, J, Dewit, O, Gut, I, Heath, S, Laukens, D, Mni, M, Rutgeerts, P, Van Gossum, A, Zelenika, D, Franchimont, D, Hugot, J-P, de Vos, M, Vermeire, S, Louis, E, Cardon, L R, Anderson, C A, Drummond, H, Nimmo, E, Ahmad, T, Prescott, N J, Onnie, C M, Fisher, S A, Marchini, J, Satsangi, J 2008, ' Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease ', Nature Genetics, vol. 40, no. 8, pp. 955-962 . https://doi.org/10.1038/ng.175
DOI:	10.1038/ng.175
Popis:	Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data from three studies on Crohn's disease ( a total of 3,230 cases and 4,829 controls) and carried out replication in 3,664 independent cases with a mixture of population-based and family-based controls. The results strongly confirm 11 previously reported loci and provide genome-wide significant evidence for 21 additional loci, including the regions containing STAT3, JAK2, ICOSLG, CDKAL1 and ITLN1. The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development.
Databáze:	OpenAIRE
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