Effect of oral clarithromycin on gall-bladder motility in normal subjects and those with gall-stones

Autor:	L. J. D. O'donnell, N. McCAULEY, S. Sengupta, P. Modak
Rok vydání:	2006
Předmět:	Adult Male medicine.medical_specialty Gallbladder Emptying Administration Oral Erythromycin Gallstones Placebo Gastroenterology Double-Blind Method Oral administration Clarithromycin Internal medicine Humans Medicine Pharmacology (medical) Antibacterial agent Cross-Over Studies Ejection fraction Hepatology business.industry digestive oral and skin physiology Fasting Middle Aged Postprandial Period Crossover study Anti-Bacterial Agents Postprandial Female business medicine.drug
Zdroj:	Alimentary Pharmacology and Therapeutics. 24:95-99
ISSN:	1365-2036 0269-2813
DOI:	10.1111/j.1365-2036.2006.02962.x
Popis:	Summary Background Motilin receptor stimulation with erythromycin has been shown to have a prokinetic effect on gall-bladder motility in human beings. Aim To find out whether oral clarithromycin has similar prokinetic activity to erythromycin on fasting and postprandial gall-bladder emptying in normal humans and those with gall-stone disease. Methods In a blinded two-way crossover study clarithromycin 500 mg and a placebo were administered to 10 normal subjects and 10 subjects with gall-stone disease. Gall-bladder volumes were assessed in the fasting and postprandial state. Results Fasting volumes were significantly less following clarithromycin administration in both normal subjects and subjects with gall-stones compared with placebo (12.1 ± 1.8 mL vs. 17.8 ± 2.0 mL, P
Databáze:	OpenAIRE
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