Prevention of Salicylate Teratogenicity in Immobilized Rats by Certain Central Nervous System Depressants
| Autor: | Allen S. Goldman, William C. Yakovac |
|---|---|
| Rok vydání: | 1964 |
| Předmět: |
medicine.medical_specialty
Pentobarbital Chlorpromazine medicine.drug_class Sodium Salicylate Central nervous system Maternal morbidity Pharmacology Toxicology General Biochemistry Genetics and Molecular Biology Immobilization chemistry.chemical_compound Pregnancy Internal medicine medicine Fetal Death Sodium salicylate Research Abnormalities Drug-Induced Central Nervous System Depressants medicine.disease Salicylates Rats Endocrinology medicine.anatomical_structure chemistry embryonic structures Pregnancy Animal Gestation Depressant medicine.drug |
| Zdroj: | Experimental Biology and Medicine. 115:693-696 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-115-29009 |
| Popis: | SummaryPrior treatment of pregnant rats with the central nervous system depressants, sodium pentobarbital or chlorpromazine, prevents the augmentation by maternal immobilization of the maternal morbidity and teratogenic action induced by sodium salicylate on the tenth day of gestation. The prevention by either central depressant of the production of congenital malformations in immobilized animals given otherwise non-teratogenic doses of salicylate appears to be mediated through the maternal central nervous system. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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