Self-reported rates of impulsivity in Parkinson's Disease
| Autor: | Hakmook Kang, Megan A. Aumann, Ya-Chen Lin, Elise B. Bradley, Shelby B. Hughes, Adam J. Stark, Daniel O. Claassen, David H. Zald |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Parkinson's disease media_common.quotation_subject Population Dopamine Agents Neurosciences. Biological psychiatry. Neuropsychiatry Audiology Impulsivity Self-Control Diagnostic Self Evaluation Executive Function Dopamine medicine Humans Attention Cognitive Dysfunction RC346-429 education Research Articles media_common Aged education.field_of_study business.industry General Neuroscience Dopaminergic Attentional control Cognition Parkinson Disease Self-control Middle Aged medicine.disease Impulsive Behavior Female Neurology. Diseases of the nervous system Neurology (clinical) Self Report medicine.symptom business RC321-571 medicine.drug Research Article |
| Zdroj: | Annals of Clinical and Translational Neurology Annals of Clinical and Translational Neurology, Vol 7, Iss 4, Pp 437-448 (2020) |
| ISSN: | 2328-9503 |
| Popis: | Objective Impulsive decision‐making is characterized by actions taken without considering consequences. Patients with Parkinson's disease (PD) who receive dopaminergic treatment, especially dopamine agonists, are at risk of developing impulsive–compulsive behaviors (ICBs). We assessed impulse‐related changes across a large heterogeneous PD population using the Barratt impulsivity scale (BIS‐11) by evaluating BIS‐11 first‐ and second‐order factors. Methods We assessed a total of 204 subjects: 93 healthy controls (HCs), and 68 ICB– and 43 ICB + PD patients who completed the BIS‐11. Using a general linear model and a least absolute shrinkage and selection operation regression, we compared BIS‐11 scores between the HC, ICB– PD, and ICB + PD groups. Results Patients with PD rated themselves as more impulsive than HCs in the BIS‐11 total score, second‐order attention domain, and first‐order attention and self‐control domains. ICB + patients recorded higher total scores as well as higher scores in the second‐order non‐planning domain and in self‐control and cognitive complexity than ICB– patients. Interpretation These results indicate that the patients with PD show particular problems with attentional control, whereas ICB + patients show a distinct problem in cognitive control and complexity. Additionally, it appears that all patients with PD are more impulsive than their age‐ and sex‐matched healthy peers. Increased impulsivity may be a result of the disease course, or attributed to dopaminergic medication use, but these results emphasize the importance of the cognitive components of impulsivity in patients with PD. |
| Databáze: | OpenAIRE |
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