Molecular epidemiology of enterovirus 71 in peninsular Malaysia, 1997?2000
Autor: | K. B. Chua, B. H. Chua, Lara J. Herrero, C. S. M. Lee, Robert J. Hurrelbrink, Peter C. McMinn |
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Rok vydání: | 2003 |
Předmět: |
medicine.medical_specialty
Genotype Biology medicine.disease_cause Disease Outbreaks Medical microbiology Virology Consensus Sequence Case fatality rate Enterovirus Infections medicine Enterovirus 71 Humans Amino Acid Sequence Phylogeny DNA Primers Enterovirus Molecular Epidemiology Base Sequence Geography Molecular epidemiology Reverse Transcriptase Polymerase Chain Reaction Incidence Malaysia virus diseases Aseptic meningitis Outbreak General Medicine medicine.disease biology.organism_classification Hand Foot and Mouth Disease Sequence Alignment Encephalitis |
Zdroj: | Archives of Virology. 148:1369-1385 |
ISSN: | 1432-8798 0304-8608 |
Popis: | Human enterovirus 71 (EV71) (genus Enterovirus, family Picornaviridae) has been responsible for sporadic cases and outbreaks of hand-foot-and-mouth disease (HFMD), aseptic meningitis, encephalitis and poliomyelitis-like disease in Europe, the U.S.A., Australia and Asia. Recently, there has been an increase in EV71 activity in the Asia-Pacific region, with many outbreaks of HFMD associated with brainstem encephalitis manifesting as neurogenic pulmonary oedema with a high case fatality rate. In 1997, and again in 2000, EV71 outbreaks occurred in peninsular Malaysia. Variations in VP1 gene sequences have been shown to divide all known EV71 field isolates into three distinct genogroups (A, B and C). Consequently we examined the VP1 gene sequences of 43 EV71 strains isolated in peninsular Malaysia between 1997 and 2000 in order to determine the genogroup prevalence over the period. In this study we show that four subgenogroups (B3, B4, C1 and C2) of EV71 circulated in peninsular Malaysia between 1997 and 2000. Subgenogroups B3, B4 and C1 have been identified as the primary cause of the outbreaks of EV71 in peninsular Malaysia. Subgenogroup C1 also displayed endemic circulation from 1997 to 2000 and subgenogroup C2 was present at a low level during the 1997 outbreak. |
Databáze: | OpenAIRE |
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