Characterization of the encoding properties of intraspinal mechanosensory neurons in the lamprey
| Autor: | Eric D. Tytell, Tim Kiemel, Allan L. Yau, Nicole Massarelli, Kathleen A. Hoffman |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Physiology Water flow Action Potentials Sensory system Synapse 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine biology.animal Physical Stimulation Animals Ecology Evolution Behavior and Systematics Ichthyomyzon unicuspis Analysis of Variance biology Lamprey Vertebrate Central pattern generator Lampreys biology.organism_classification Adaptation Physiological 030104 developmental biology Spike sorting Spinal Cord Animal Science and Zoology Neuroscience Mechanoreceptors 030217 neurology & neurosurgery |
| Zdroj: | Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology. 203(10) |
| ISSN: | 1432-1351 |
| Popis: | Proprioceptive sensory inputs are an integral part of the closed-loop system of locomotion. In the lamprey, a model organism for vertebrate locomotion, such sensory inputs come from intraspinal mechanosensory cells called “edge cells”. These edge cells synapse directly onto interneurons in the spinal central pattern generator (CPG) circuit and allow the CPG to adjust the motor output according to how the body is bending. However, the encoding properties of the edge cells have never been fully characterized. To identify these properties and better understand edge cells’ role in locomotion, we isolated spinal cords of silver lampreys (Ichthyomyzon unicuspis) and recorded extracellularly from the lateral tracts where edge cell axons are located. We identified cells that responded to mechanical stimuli and used standard spike sorting algorithms to identify separate units, then examined how the cells respond to bending rate and bending angle. Although some cells respond to the bending angle, as was previously known, the strongest and most common responses were to bending velocity. These encoding properties will help us better understand how lampreys and other basal vertebrates adapt their locomotor rhythms to different water flow patterns, perturbations, or other unexpected changes in their environments. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink