Associations between vitamin D, adiposity, and respiratory symptoms in chronic spinal cord injury
Autor: | Palak Walia, Antonio A. Lazzari, Merilee Teylan, Carlos G. Tun, Eric Garshick, Jaime E. Hart, Rebekah L. Goldstein |
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Rok vydání: | 2017 |
Předmět: |
Adult
Male medicine.medical_specialty Context (language use) 03 medical and health sciences 0302 clinical medicine Wheeze Internal medicine Vitamin D and neurology Humans Medicine 030212 general & internal medicine Vitamin D Veterans Affairs Spinal cord injury Spinal Cord Injuries Research Articles Adiposity Aged business.industry Respiration Respiratory disease Odds ratio Middle Aged medicine.disease Chronic cough 030228 respiratory system Physical therapy Female Neurology (clinical) medicine.symptom business |
Zdroj: | The Journal of Spinal Cord Medicine. 41:667-675 |
ISSN: | 2045-7723 1079-0268 |
Popis: | Context/Objective Persons with chronic spinal cord injury (SCI) have an increased risk of respiratory-related morbidity and mortality and chronic respiratory symptoms are clinical markers of future respiratory disease. Therefore, we sought to assess potentially modifiable factors associated with respiratory symptoms, with a focus on circulating vitamin D and measures of body fat. Design Cross-sectional study. Setting Veterans Affairs Medical Center. Participants Three hundred forty-three participants (282 men and 61 women) with chronic SCI participating in an epidemiologic study to assess factors influencing respiratory health recruited from VA Boston and the community. Methods Participants provided a blood sample, completed a respiratory health questionnaire, and underwent dual x-ray absorptiometry (DXA) to assess % body fat. Logistic regression was used to assess cross-sectional associations between respiratory symptoms and plasma vitamin D and measures of body fat with adjustment for a number of potential confounders. Outcome Measures Chronic cough, chronic phlegm, any wheeze, persistent wheeze. Results After adjustment for a number of confounders (including smoking), participants with greater %-android, gynoid, trunk, or total body fat had increased odds ratios for any wheeze and suggestive associations with persistent wheeze, but not with chronic cough or phlegm. Vitamin D levels were not associated with any of the respiratory symptoms. Conclusion Increased body fat, but not vitamin D, was associated with wheeze in chronic SCI independent of a number of covariates. |
Databáze: | OpenAIRE |
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