Preparation and Characterization of Poly(2-oxazoline) Micelles for the Solubilization and Delivery of Water Insoluble Drugs
| Autor: | Alexander V. Kabanov, Salma H. Azam, Amanda E.D. Van Swearingen, Elizabeth Wayne, Natasha Vinod, Chad V. Pecot, Marina Sokolsky-Papkov, Sloane Christian Fussell, Duhyeong Hwang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Active ingredient Drug Aqueous solution Strategy and Management Mechanical Engineering media_common.quotation_subject Metals and Alloys Polymer Oxazoline Combinatorial chemistry Micelle Industrial and Manufacturing Engineering Solvent chemistry.chemical_compound Drug development chemistry Methods Article media_common |
| Zdroj: | Bio Protoc |
| Popis: | Many new drug development candidates are highly lipophilic compounds with low water solubility. This constitutes a formidable challenge for the use of such compounds for cancer therapy, where high doses and intravenous injections are needed ( Di et al., 2012 ). Here, we present a poly(2-oxazoline) polymer (POx)-based nanoformulation strategy to solubilize and deliver hydrophobic drugs. POx micelles are prepared by a simple thin-film hydration method. In this method, the drug and polymer are dissolved in a common solvent and allowed to mix, following which the solvent is evaporated using mild heating conditions to form a thin film. The micelles form spontaneously upon hydration with saline. POx nanoformulation of hydrophobic drugs is unique in that it has a high drug loading capacity, which is superior to micelles of conventional surfactants. Moreover, multiple active pharmaceutical ingredients (APIs) can be included within the same POx micelle, thereby enabling the codelivery of binary as well as ternary drug combinations ( Han et al., 2012 ; He et al., 2016 ). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|