Elevated Soluble Platelet Glycoprotein VI Levels in Patients After Living Donor Liver Transplantation
| Autor: | Shuji Isaji, Toshiki Mastsui, Masanobu Usui, Katsuki Naitoh, Takeshi Matsumoto, Naoki Takahashi, Shinji Uemoto, Toshihiko Kobayashi, Hideo Wada |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Time Factors medicine.medical_treatment ADAMTS13 Protein Platelet Membrane Glycoproteins 030204 cardiovascular system & hematology Liver transplantation Platelet membrane glycoprotein Gastroenterology 03 medical and health sciences 0302 clinical medicine Von Willebrand factor Internal medicine von Willebrand Factor Disintegrin Living Donors Medicine Humans Platelet Platelet activation Survivors Thrombospondin biology business.industry Platelet Count Hematology General Medicine Platelet Activation ADAMTS13 Liver Transplantation 030104 developmental biology Solubility Immunology biology.protein business |
| Zdroj: | Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. 23(3) |
| ISSN: | 1938-2723 |
| Popis: | Plasma-soluble platelet glycoprotein VI (sGPVI) levels were examined in patients undergoing living donor liver transplantation (LDLT), and the relationship between platelet activation and thrombocytopenia was evaluated to understand the mechanism of thrombocytopenia in LDLT. Platelet counts were significantly higher in the donors compared to the recipient, and the plasma sGPVI levels increased in both groups after the operation. Regarding the relationship between the platelet counts and the sGPVI levels, the slope varied on different days, and it became negative on day 3, suggesting that the plasma sGPVI levels are related to platelet activation in LDLT. The frequency of complications was high in the nonsurvivors. The platelet counts were higher in the survivors than in the nonsurvivors on days 14 and 28. Although the plasma levels of sGPVI in the survivors increased after the operation, those in the nonsurvivors were high only on day 3. Although the ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 domain, member 13) levels were markedly reduced, von Willebrand factor (VWF) and VWF propeptide (VWFpp) were markedly elevated during LDLT. The antithrombin activity was significantly lower (day 14) and VWFpp (day 28) was significantly higher in the nonsurvivors than in the survivors. These findings suggest that platelet activation first occurs after LDLT, and it is high in the nonsurvivors on day 3. Thereafter, the hemostatic abnormality and vascular endothelial cell injuries may appear on days 14 and 28. |
| Databáze: | OpenAIRE |
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