The number of insults and the cerebral damage after hypoxia/ischemia are altered after acute pretreatment with corticosterone and metyrapone
| Autor: | Harm J. Krugers, Jakob Korf, A. Wiersma, G.J. Ter Horst, S Knollema, Richard H.A. Kemper |
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| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Ischemia ASTROCYTES Hypoxia ischemia REDUCES BRAIN-DAMAGE RATS HIPPOCAMPAL DAMAGE chemistry.chemical_compound Corticosterone Neuronal damage PITUITARY Internal medicine INJURY medicine neuronal damage Stroke silver staining seizures Metyrapone business.industry CORTISOL General Neuroscience Adrenalectomy EARLY SEIZURES medicine.disease stroke Endocrinology chemistry GLUCOCORTICOID ENDANGERMENT Cerebral damage business ACUTE STROKE medicine.drug |
| Zdroj: | Neuroscience research communications, 21(3), 203-211 |
| ISSN: | 1520-6769 0893-6609 |
| DOI: | 10.1002/(sici)1520-6769(199711/12)21:3<203::aid-nrc225>3.0.co;2-h |
| Popis: | The role of glucocorticoids in neuronal viability is controversial. Most studies which describe the effects of glucocorticoids on ischemic brain damage use surgical adrenalectomy to induce a reduction in plasma corticosterone levels. In the present study we used metyrapone, a corticosterone synthesis inhibitor, to examine the effects of acute manipulation of corticosterone levels on neuronal damage and seizures. Shortly before transient hypoxia/ischemia, animals were subcutaneously injected with sesame oil, metyrapone, corticosterone or corticosterone + metyrapone. Both the neuronal damage and the percentage animals with seizures were found to correlate well with plasma corticosterone levels. This relation between affected area, seizures and corticosterone levels was confirmed when the rats were re-arranged into animals with and without seizures. However, Corticosterone administration in metyrapone treated rats did not result (compared to MET treatment) in an increased neuronal damage. This suggests that the beneficial effects of metyrapone may be regulated by a corticosterone independent mechanism. |
| Databáze: | OpenAIRE |
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