Mr Imaging of Acute Myocardial Infarction in Pigs Using Gd-DTPA-Labeled Dextran
| Autor: | Rickard Nyman, Anders Ericsson, Gerhard Wikström, Anders Hemmingsson, M. Wikström, Anders Waldenström, H. J. Martinussen |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Gadolinium DTPA
Swine Myocardial Infarction Contrast Media Infarction 030218 nuclear medicine & medical imaging Blood substitute 03 medical and health sciences 0302 clinical medicine In vivo Occlusion medicine Animals Radiology Nuclear Medicine and imaging cardiovascular diseases Myocardial infarction Ligation Radiological and Ultrasound Technology medicine.diagnostic_test business.industry Dextrans Magnetic resonance imaging General Medicine Pentetic Acid Image Enhancement medicine.disease Magnetic Resonance Imaging Contrast medium 030220 oncology & carcinogenesis cardiovascular system Nuclear medicine business Ex vivo |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1600-0455 0284-1851 |
| DOI: | 10.1080/02841859209173183 |
| Popis: | Myocardial infarctions were induced in 12 pigs. In 6 pigs, dextran-(Gd-DTPA)15 (≈0.1 mmol Gd/kg b.w.) was injected i.v. 4 to 4.5 hours after coronary artery occlusion. ECG gated MR images were obtained repeatedly before (n = 4) and after (n = 6) contrast medium injection. Relaxation times in blood samples were measured repeatedly. The animals were sacrificed 2 hours after contrast medium administration. The hearts were excised, reexamined in the MR equipment and stained with triphenyltetrazolium chloride (TTC) in order to define areas of infarction. The remaining 6 pigs were sacrificed 6 hours after occlusion without administration of contrast medium. These hearts were only imaged ex vivo. In vivo, the infarctions could not be identified with or without dextran-(Gd-DTPA)15. Ex vivo, without contrast medium, the infarctions had an increased signal intensity, most pronounced in the T2-weighted images. Dextran-(Gd-DTPA)15 caused a prolonged, pronounced shortening of T1 and T2 in blood samples. The infarct demarcation improved in the T1-weighted images after injection of dextran-(Gd-DTPA)15, due to a moderate enhancement in normal myocardium and a stronger enhancement at the periphery of the infarctions, while the central parts of the infarctions were only weakly enhanced. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|