Association between fibroblast growth factor receptor-2 gene polymorphism and risk of breast cancer in Chinese populations: A HuGE review and meta-analysis
| Autor: | Wei-Ming Wang, Wei Huang, Zhan-Xue Zhao, Yan-Li Tan, Yong-Bin Yang, Hui Liu |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Risk China Single-nucleotide polymorphism Breast Neoplasms Bioinformatics lcsh:RC254-282 Polymorphism Single Nucleotide polymorphism 03 medical and health sciences Breast cancer 0302 clinical medicine Asian People Genetic model Genetic predisposition Odds Ratio Medicine Humans Radiology Nuclear Medicine and imaging Genetic Predisposition to Disease Receptor Fibroblast Growth Factor Type 2 Alleles Genetic Association Studies Genetic association Chinese business.industry General Medicine Odds ratio lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens 030104 developmental biology meta.analysis Oncology Genetic marker FGFR2 030220 oncology & carcinogenesis Meta-analysis Female Gene polymorphism business Publication Bias |
| Zdroj: | Journal of Cancer Research and Therapeutics, Vol 12, Iss 2, Pp 543-549 (2016) |
| ISSN: | 1998-4138 |
| Popis: | Aim of study: To evaluate the effect of fibroblast growth factor receptor.2. (FGFR2) on genetic susceptibility for breast cancer. (BC) in Chinese populations. Materials and Methods: A computerized literature search was carried out in PubMed, Chinese Biomedical Database. (CBM), and Chinese National Knowledge Infrastructure. (CNKI) to collect relevant articles. Pooled odds ratio. (OR) and 95% confidence interval. (CI) were used to assess the strength of the associations. Results: A total of 21 articles involving a total of 15 polymorphisms of the FGFR2 gene were included in the meta-analysis. Due to the limited studies for rs17102287, rs2981578, rs3135718, rs3803662, rs3750817, rsl0510097, rsl7542768, rs13387042, and rs1982073; we only pooled the six polymorphisms. (rs11200014, rs1219648, rs2420946, rs2912778, rs2981579, and rs2981582) into this meta.analysis. Overall, significantly increased BC risk was associated with five polymorphisms. (rs2981579, rs2981582, rs1219648, rs2420946, and rs2912778) when all studies were pooled into the meta.analysis. When stratified by ethnicity and source of controls, similar results were also detected. However, for rs2981579 no significant association was found among Chinese Han in all genetic models. Conclusion: Our meta-analysis suggests that FGFR2 is likely an important genetic marker contributing to susceptibility of BC. We recommend that these single nucleotide polymorphisms to be included in future association studies and functional assays. |
| Databáze: | OpenAIRE |
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