Autor: |
Martin-Jan Smit, Jac C. H. M. Wijkmans, Rong-Qiang Liu, Jaap van der Louw, Koc-Kan Ho, Jim Inglese, Shawn David Erickson, Ming You, Ellen Son, Andrew Laird Roughton, Douglas S. Auld, G.M.T. Vogel, Christopher M. Masterson, Paolo Conti, Daming Feng, Martijn Rooseboom, Adolph Bohnstedt, Celia Kingsbury, Maria L. Webb, Steven G. Kultgen, Yajing Rong, Michael Ohlmeyer, Philippe Samama, Wim Dokter |
Rok vydání: |
2006 |
Předmět: |
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Zdroj: |
Bioorganic & Medicinal Chemistry Letters. 16:2724-2728 |
ISSN: |
0960-894X |
Popis: |
An imidazolylpyrimidine was identified in a CXCR2 chemokine receptor antagonist screen and was optimized for potency, in vitro metabolic stability, and oral bioavailability. It was found that subtle structural modification within the series affected the oral bioavailability. Potent and orally available CXCR2 antagonists are herein reported. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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