Developmental characteristics of picrotoxin-induced convulsions in rats with genetic absence epilepsy
| Autor: | Any Boehrer, M. Vergnes, Astrid Nehlig |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Aging Ontogeny Convulsants Neurological disorder Central nervous system disease GABA Antagonists Epilepsy chemistry.chemical_compound Developmental Neuroscience Seizures Internal medicine Convulsion medicine Animals Picrotoxin GABA-A Receptor Antagonists Rats Wistar Brain Electroencephalography medicine.disease Rats Endocrinology Neurology chemistry Epilepsy Absence Anesthesia medicine.symptom Psychology Spike wave |
| Zdroj: | Experimental neurology. 184(1) |
| ISSN: | 0014-4886 |
| Popis: | Adult rats with genetic absence epilepsy (GAERS) were shown to be hyperresponsive to convulsions induced by picrotoxin compared to nonepileptic controls (NERs). In contrast, young GAERS aged 22-26 days were less responsive than NERs to picrotoxin-induced convulsions. Around 30 days of age, when spontaneous spike-wave discharges develop in GAERS, the sensitivity of both strains did no longer differ. After 40 days of age, GAERS appeared definitely more prone than NERs to convulse in response to picrotoxin injection. A developmental imbalance in excitation/inhibition may parallel the occurrence of SWDs. |
| Databáze: | OpenAIRE |
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