Author Correction: A Novel S100A8/A9 Induced Fingerprint of Mesenchymal Stem Cells associated with Enhanced Wound Healing
| Autor: | Florian Gebhard, Karmveer Singh, Anca Sindrilaru, Saira Munir, Abhijit Basu, Diana Crisan, Meinhard Wlaschek, Karin Scharffetter-Kochanek, Markus Huber-Lang, Nicolai Treiber, Medanie A. Mulaw |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Multidisciplinary 010405 organic chemistry business.industry 030106 microbiology Fingerprint (computing) Mesenchymal stem cell lcsh:R lcsh:Medicine 01 natural sciences 0104 chemical sciences Cell biology 03 medical and health sciences ComputingMethodologies_DOCUMENTANDTEXTPROCESSING Medicine lcsh:Q business S100a8 a9 Wound healing lcsh:Science Author Correction |
| Zdroj: | Scientific Reports Scientific Reports, Vol 8, Iss 1, Pp 1-2 (2018) |
| ISSN: | 2045-2322 |
| Popis: | We here investigated whether the unique capacity of mesenchymal stem cells (MSCs) to re-establish tissue homeostasis depends on their potential to sense danger associated molecular pattern (DAMP) and to mount an adaptive response in the interest of tissue repair. Unexpectedly, after injection of MSCs which had been pretreated with the calcium-binding DAMP protein S100A8/A9 into murine full-thickness wounds, we observed a significant acceleration of healing even exceeding that of non-treated MSCs. This correlates with a fundamental reprogramming of the transcriptome in S100A8/A9 treated MSCs as deduced from RNA-seq analysis and its validation. A network of genes involved in proteolysis, macrophage phagocytosis, and inflammation control profoundly contribute to the clean-up of the wound site. In parallel, miR582-5p and genes boosting energy and encoding specific extracellular matrix proteins are reminiscent of scar-reduced tissue repair. This unprecedented finding holds substantial promise to refine current MSC-based therapies for difficult-to-treat wounds and fibrotic conditions. |
| Databáze: | OpenAIRE |
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