Impact of lean mass and bone density on glomerular filtration rate estimation in people living with HIV/AIDS
| Autor: | Rachida Inaoui, Jérôme Tourret, Laurence Pieroni, Corinne Isnard Bagnis, Sophie Tezenas du Montcel, Stéphanie Lallauret, Christine Katlama, Gilbert Deray, Marie Courbebaisse, Philippe Maksud, Marc-Antoine Valantin, Roland Tubiana |
|---|---|
| Přispěvatelé: | Service de Néphrologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université Pierre et Marie Curie - Paris 6 (UPMC), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de Rhumatologie [CHU Pitié Salpêtrière], Service de Médecine nucléaire [CHU Pitié-Salpétrière], Département de Biostatistique, Santé Publique et Information Médicale [CHU Pitié-Salpêtrière] (BIOSPIM ), Service de Maladies Infectieuses et Tropicales [CHU Pitié-Salpêtrière], Service de Neuroradiologie [CHU Pitié-Salpêtrière], Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Institut Necker Enfants-Malades (INEM - UM 111 (UMR 8253 / U1151)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), HAL UPMC, Gestionnaire |
| Rok vydání: | 2017 |
| Předmět: |
Male
RNA viruses Bone density Physiology [SDV]Life Sciences [q-bio] 030232 urology & nephrology lcsh:Medicine HIV Infections Blood Pressure Pathology and Laboratory Medicine urologic and male genital diseases Biochemistry Vascular Medicine chemistry.chemical_compound Absorptiometry Photon 0302 clinical medicine Immunodeficiency Viruses Bone Density Chronic Kidney Disease Medicine and Health Sciences 030212 general & internal medicine lcsh:Science reproductive and urinary physiology Multidisciplinary biology HIV diagnosis and management Middle Aged female genital diseases and pregnancy complications [SDV] Life Sciences [q-bio] Nephrology Medical Microbiology Connective Tissue Creatinine Viral Pathogens Viruses Hypertension Body Composition Female Pathogens Anatomy Glomerular Filtration Rate Research Article medicine.medical_specialty Urology Renal function Context (language use) Microbiology 03 medical and health sciences Diabetes mellitus Retroviruses medicine Humans Bone Microbial Pathogens Aged Renal Physiology business.industry lcsh:R Lentivirus Organisms Biology and Life Sciences HIV Renal System medicine.disease Diagnostic medicine Cross-Sectional Studies Biological Tissue Cystatin C chemistry biology.protein Lean body mass lcsh:Q business Biomarkers Kidney disease |
| Zdroj: | PLoS ONE PLoS One PLoS One, 2017, 12 (11), pp.e0186410. ⟨10.1371/journal.pone.0186410⟩ PLoS ONE, Vol 12, Iss 11, p e0186410 (2017) ResearcherID |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0186410 |
| Popis: | International audience; Context: Chronic kidney disease is a frequent complication in persons living with HIV/AIDS. Although previous studies have suggested that the CKD-EPI formula is appropriate to estimate glomerular filtration rate (GFR) in HIV-positive adults with normal kidney function, the optimal way to estimate GFR in those with Stage 3 chronic kidney disease is not known. Moreover, the impact of muscle mass on creatinine level and GFR estimation is unknown.Aim and methods: Our study aimed to evaluate the accuracy of different diagnostic tests available compared to the gold standard measurement of GFR. A group of 44 HIV-1 patients with an estimated GFR between 60 and 30 ml/min/1.73 m2 were included in a single-center cross-sectional study. Serum creatinine and cystatin C were measured. GFR was estimated using Cockcroft-Gault, MDRD, sMDRD, CKD-EPI, CKD-EPIcyst, and CKD-EPIcyst/creat formulae and was measured using isotopic Chrome51 EDTA clearance. Bone density and muscle mass were measured by DXA scan.Results: Mean age was 62±10 years. Mean BMI was 23±4 kg/m2. Prevalence of diabetes was 30% and of hypertension was 47%. Viral load was |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|