Antifungal Activity of Maytenin and Pristimerin

Autor: Maria José Soares Mendes-Giannini, Julhiany de Fátima da Silva, Vanderlan da Silva Bolzani, Maysa Furlan, Ana Marisa Fusco-Almeida, Vania A. F. F. M. Santos, Nayla de Souza Pitangui, Ana Elizabete Silva, Suélen A. Rossi, Haroldo Cesar de Oliveira, Janaina de Cássia Orlandi Sardi, Fernanda Patrícia Gullo, Luciana Arantes Soares, Fernanda Sangalli-Leite, Dulce Helena Siqueira Silva
Přispěvatelé: Universidade Estadual Paulista (Unesp)
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Zdroj: Evidence-Based Complementary and Alternative Medicine, Vol 2012 (2012)
Evidence-based Complementary and Alternative Medicine : eCAM
Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
ISSN: 1741-4288
Popis: Made available in DSpace on 2013-08-28T14:07:16Z (GMT). No. of bitstreams: 1 WOS000304986200001.pdf: 1785249 bytes, checksum: 06bf19101a9b8d25192d31f4e0b427ba (MD5) Made available in DSpace on 2013-09-30T18:05:49Z (GMT). No. of bitstreams: 2 WOS000304986200001.pdf: 1785249 bytes, checksum: 06bf19101a9b8d25192d31f4e0b427ba (MD5) WOS000304986200001.pdf.txt: 28441 bytes, checksum: c798f5de65b058ea2d5fbca65adbe21d (MD5) Previous issue date: 2012-01-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T14:20:49Z No. of bitstreams: 2 WOS000304986200001.pdf: 1785249 bytes, checksum: 06bf19101a9b8d25192d31f4e0b427ba (MD5) WOS000304986200001.pdf.txt: 28441 bytes, checksum: c798f5de65b058ea2d5fbca65adbe21d (MD5) Made available in DSpace on 2014-05-20T14:20:49Z (GMT). No. of bitstreams: 2 WOS000304986200001.pdf: 1785249 bytes, checksum: 06bf19101a9b8d25192d31f4e0b427ba (MD5) WOS000304986200001.pdf.txt: 28441 bytes, checksum: c798f5de65b058ea2d5fbca65adbe21d (MD5) Previous issue date: 2012-01-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Pró-Reitoria de Pesquisa da UNESP (PROPe UNESP) Fungal infections in humans have increased alarmingly in recent years, particularly in immunocompromised individuals. Among the infections systemic candidiasis, aspergillosis, cryptococcosis, paracoccidioidomycosis, and histoplasmosis mortality are more prevalent and more severe in humans. The current high incidence of dermatophytosis is in humans, especially as the main etiologic agents Trichophyton rubrum and Trichophyton mentagrophytes. Molecules pristimerin and maytenin obtained from the plant Maytenus ilicifolia (Celastraceae) are known to show various pharmacological activities. This study aimed to evaluate the spectrum of antifungal activity of maytenin and pristimerin and their cytotoxicity in human keratinocytes (NOK cells of the oral mucosa). It was concluded that the best spectrum of antifungal activity has been shown to maytenin with MIC varying from 0.12 to 125 mg/L, although it is also active with pristimerin MIC ranging between 0.12 and 250 mg/L. Regarding the toxicity, both showed to have high IC50. The SI showed high pristimerin against some species of fungi, but SI maytenin was above 1.0 for all fungi tested, showing a selective action of fungi. However, when comparing the two substances, maytenin also showed better results. The two molecules can be a possible prototype with a broad spectrum of action for the development of new antifungal agents. UNESP, Fac Pharmaceut Sci, Dept Clin Anal, Lab Clin Mycol, BR-14801902 Araraquara, SP, Brazil UNESP, Inst Chem, BR-14800900 Araraquara, SP, Brazil UNESP, Fac Pharmaceut Sci, Dept Clin Anal, Lab Clin Mycol, BR-14801902 Araraquara, SP, Brazil UNESP, Inst Chem, BR-14800900 Araraquara, SP, Brazil
Databáze: OpenAIRE
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