Magnetically-responsive silica-gold nanobowls for targeted delivery and SERS-based sensing
| Autor: | Chen Zhang, Gennadi V. Glinsky, Tianyu Lu, Alexander H. Mo, Heemin Kang, Siddhartha Akkiraju, Samuel Dossou, Ratnesh Lal, Vrinda Sant, Karla Santacruz Gomez, David A. Colburn, Kuo-Fen Lee, Joon Lee, Shyni Varghese, Woraphong Janetanakit, Yue Cao, Preston B. Landon |
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| Rok vydání: | 2016 |
| Předmět: |
Materials science
Composite number Nanotechnology 02 engineering and technology 010402 general chemistry Spectrum Analysis Raman 01 natural sciences Article symbols.namesake chemistry.chemical_compound Colloid Cell Line Tumor Molecule Humans General Materials Science Fourier transform infrared spectroscopy technology industry and agriculture Surface-enhanced Raman spectroscopy 021001 nanoscience & nanotechnology equipment and supplies Silicon Dioxide 0104 chemical sciences chemistry symbols Magnetic nanoparticles Nanoparticles Polystyrenes Polystyrene Gold 0210 nano-technology Raman spectroscopy human activities |
| Zdroj: | Nanoscale. 8(23) |
| ISSN: | 2040-3372 |
| Popis: | Composite colloidal structures with multi-functional properties have wide applications in targeted delivery of therapeutics and imaging contrast molecules and high-throughput molecular bio-sensing. We have constructed a multifunctional composite magnetic nanobowl using the bottom-up approach on an asymmetric silica/polystyrene Janus template consisting of a silica shell around a partially exposed polystyrene core. The nanobowl consists of a silica bowl and a gold exterior shell with iron oxide magnetic nanoparticles sandwiched between the silica and gold shells. The nanobowls were characterized by electron microscopy, atomic force microscopy, magnetometry, vis-NIR and FTIR spectroscopy. Magnetically vectored transport of these nanobowls was ascertained by time-lapsed imaging of their flow in fluid through a porous hydrogel under a defined magnetic field. These magnetically-responsive nanobowls show distinct surface enhanced Raman spectroscopy (SERS) imaging capability. The PEGylated magnetically-responsive nanobowls show size-dependent cellular uptake in vitro. |
| Databáze: | OpenAIRE |
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