Production of a Potent Vaccine from the Attenuated M-44 Strain of Coxiella burneti
| Autor: | David M. Robinson, Sherman E. Hasty |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Clinical Microbiology and Immunology
Hot Temperature Virulence General Immunology and Microbiology Strain (chemistry) Complement Fixation Tests Guinea Pigs General Medicine Biology Vaccines Attenuated Virology General Biochemistry Genetics and Molecular Biology Body Temperature Microbiology Bacterial vaccine Coxiella Evaluation Studies as Topic Antibody Formation Bacterial Vaccines Animals Immunization General Pharmacology Toxicology and Pharmaceutics Q Fever Antibody formation |
| Zdroj: | Applied Microbiology. 27:777-783 |
| ISSN: | 0003-6919 |
| DOI: | 10.1128/am.27.4.777-783.1974 |
| Popis: | The attenuated M-44 strain of Coxiella burneti was heated to free it of adventitious agents that may have been present. Parallel titrations of the strain before and after heating indicated that the virulence for guinea pigs was markedly decreased. Guinea pigs immunized with the strain derived after heat treatment were protected from the effects of challenge with C. burneti in either phase I or II. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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