Biochemical Profile of Nonalcoholic Fatty Liver Disease Patients in Eastern India with Histopathological Correlation
| Autor: | Pramila Kumari Mishra, Pallavi Bhuyan, Ayaskanta Singh, Jimmy Narayan, Bijay Misra, Manas Kumar Panigrahi, Prasant Parida, Niranjan Rout, Pradeep Kumar Padhi, Girish Kumar Pati, Debasis Misra, Sanjib Kumar Kar, Manorama Swain, Chudamani Meher, Shivaram Prasad Singh, Omprakash Agrawal, Kaumudee Pattnaik, Preetam Nath |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Pathology Clinical Biochemistry Gastroenterology digestive system 03 medical and health sciences 0302 clinical medicine Insulin resistance Internal medicine Nonalcoholic fatty liver disease medicine medicine.diagnostic_test business.industry Fatty liver nutritional and metabolic diseases medicine.disease digestive system diseases 030220 oncology & carcinogenesis Transaminitis Homeostatic model assessment 030211 gastroenterology & hepatology Original Article Metabolic syndrome Liver function tests business Lipid profile |
| Zdroj: | Indian journal of clinical biochemistry : IJCB. 32(3) |
| ISSN: | 0970-1915 |
| Popis: | Aminotransferase assay is often used as a screening test as well as an endpoint for resolution of disease in nonalcoholic fatty liver disease (NAFLD). Aim of the study was to evaluate the relationship of transaminase level with metabolic variables and histology in NAFLD. Single center observational study was conducted in a gastroenterology clinic at Cuttack in coastal Odisha. Subjects were consecutive patients presenting with functional bowel disease and undergoing abdominal sonography. All participants were evaluated for the presence of metabolic syndrome (MS), insulin resistance, liver function test and lipid profile. Various parameters were compared between NAFLD subjects and controls. 53.5 % of NAFLD had normal serum transaminases, whereas 20.8 % of healthy controls had transaminitis. NAFLD patients had significantly higher BMI, fasting plasma glucose, serum transaminases, serum triglycerides, serum insulin and homeostatic model assessment (HOMA) IR than controls. NAFLD patients who had transaminitis had significantly higher incidence of MS and higher mean HOMA IR than those without. There was no significant difference in histopathological features between NAFLD with and without transaminitis. To conclude, over half of NAFLD subjects do not have transaminitis while transaminitis is present in a fifth of healthy people without fatty liver. Hence serum transaminase should not be used as screening test for NAFLD. NAFLD patients with transaminitis had a higher incidence of MS and insulin resistance than those without. However, there was no significant difference in histopathological features between these two groups. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink