Enhancement of Hepatic Drug Metabolism with Dietary Cholesterol in the Rat
| Autor: | Matti Laitinen |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Cytochrome Cytochrome c reductase Toxicology Cholesterol Dietary Hydroxylation chemistry.chemical_compound Cytochrome P-450 Enzyme System Internal medicine medicine Animals Glucuronosyltransferase Cytochrome Reductases Phospholipids Pharmacology Nitroanisole O-Demethylase biology Cholesterol Fatty Acids Reverse cholesterol transport Rats Endocrinology chemistry Microsomes Liver biology.protein Microsome lipids (amino acids peptides and proteins) Aryl Hydrocarbon Hydroxylases Drug metabolism Dietary Cholesterol |
| Zdroj: | Acta Pharmacologica et Toxicologica. 39:241-249 |
| ISSN: | 0001-6683 |
| DOI: | 10.1111/j.1600-0773.1976.tb03175.x |
| Popis: | The effect of dietary cholesterol on the biochemical composition and on the activities of drug metabolizing enzymes in the rat liver was studied. There were no statistically significant differences in the measured microsomal macrocomponents between the reference group on fat free diet and the experimental rats on 5 % cholesterol diet. However, there were marked changes in the fatty acid composition of microsomal phospholipids. The activities of cytochrome c reductase, cytochrome P–450 and p–nitroanisole o–demethylase were increased significantly during cholesterol feeding. The activitiy of aryl hydrocarbon hydroxylase remained unaffected. The activity of hepatic UDPglucuronosyltransferase was also increased very significantly with dietary cholesterol. It may be true that cholesterol affects the activities of drug metabolizing enzymes partly via changes in the membrane structure, but cholesterol may also act as an inducing compound. |
| Databáze: | OpenAIRE |
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