Heparin aerosol - effect on blood coagulation and pulmonary function
| Autor: | Margareta Blombäck, Kerstin Hägnevik, Margareta Hellgren |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Adult
Male medicine.medical_specialty Thrombin time Pulmonary function testing Internal medicine medicine Humans Platelet Blood Coagulation Lung Aerosols medicine.diagnostic_test Dose-Response Relationship Drug Chemistry Heparin Respiration Antithrombin Hematology Middle Aged Endocrinology medicine.anatomical_structure Coagulation Anesthesia Female medicine.drug Partial thromboplastin time |
| Zdroj: | Thrombosis research. 21(4-5) |
| ISSN: | 0049-3848 |
| Popis: | Heparin was administrated as an aerosol in amounts of 700, 1 300 and 2 000 IU per kg body weight to 16 volunteers on 24 occasions. The concentration of heparin was registered with a chromogenic substrate method. An absorption of heparin via the lung was noted and the concentration of heparin was increased (> 0.02 IU/ml) for 2–3 weeks after 15 inhalations. There was a wide variability in response with regard to concentration of heparin, thrombin time and activated partial thromboplastin time. No dose-response relationship was found. The level of antithrombin and platelet count were mainly unchanged. No untoward effects or changes in pulmonary function were seen. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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