When the resistance gets clingy: Pseudomonas aeruginosa harboring metallo-β-lactamase gene shows high ability to produce biofilm
| Autor: | Ana Lúcia Peixoto de Freitas, Afonso Luis Barth, Leandro Reus Rodrigues Perez, Ana Lúcia Souza Antunes |
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| Rok vydání: | 2011 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Cystic Fibrosis Biology beta-Lactams medicine.disease_cause Cystic fibrosis beta-Lactam Resistance Metallo β lactamase Microbiology Medical microbiology medicine Humans Pseudomonas Infections Gene Pseudomonas aeruginosa High ability Sputum Biofilm General Medicine biochemical phenomena metabolism and nutrition bacterial infections and mycoses medicine.disease In vitro Infectious Diseases Biofilms |
| Zdroj: | European Journal of Clinical Microbiology & Infectious Diseases. 31:711-714 |
| ISSN: | 1435-4373 0934-9723 |
| DOI: | 10.1007/s10096-011-1363-2 |
| Popis: | The ability to produce biofilm and the presence of metallo-β-lactamase (MBL) among Pseudomonas aeruginosa isolates were evaluated. A total of 91 isolates were recovered from sputa of patients with (CF, n = 44) and without (non-CF, n = 47) cystic fibrosis diagnosis. Seventy-nine (86.8%; 95% CI 78.3-92.3%) were biofilm producers. Interestingly, all isolates harboring MBL showed ability (most strong or moderate) to produce biofilm in vitro. We alert to an "overlapping of mechanisms" that together represent an even greater challenge for the treatment of pulmonary infections by P. aeruginosa. |
| Databáze: | OpenAIRE |
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