Intrasinusoidal bone marrow infiltration and splenic marginal zone lymphoma: a quantitative study
| Autor: | Laura Davico Bonino, Luigi Chiusa, Flavio Fraire, Achille Pich, Paola Bortolin, Giorgio Palestro, Alessandro Fornari, Laura Godio |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Biopsy PSL Diagnosis Differential Bone Marrow medicine Humans Neoplasm Invasiveness Splenic marginal zone lymphoma B cell Aged CD20 medicine.diagnostic_test biology business.industry Lymphoma Non-Hodgkin Splenic Neoplasms Bone Marrow Examination Organ Size Hematology General Medicine Middle Aged medicine.disease Lymphoma medicine.anatomical_structure biology.protein Female Bone marrow Bone Marrow Neoplasms business Infiltration (medical) |
| Popis: | Intrasinusoidal infiltration (ISI) is a pattern of invasion that is rarely found on bone marrow (BM) biopsies, and is considered as a hallmark of splenic marginal zone cell lymphoma (SMZL). We analysed BM biopsies showing intrasinusoidal infiltration from 54 consecutive patients with different types of lymphoma to verify if ISI quantity was a diagnostic criterion for SMZL. There were 35 primary splenic lymphoma (PSL) and 19 non-PSL; 28 SMZL, three non-splenic MZL, six mantle cell, six small lymphocytic, four follicular, four diffuse large B cell, one peripheral T cell, one lymphoplasmacytic and one anaplastic large-cell lymphoma. The quantity of BM infiltrate was assessed on CD45, CD20 and CD3 stained sections. The mean percentage of total (TI) and intrasinusoidal (ISI) lymphocytes was calculated in 10 areas for each case. TI quantity was 21.57 in PSL and 35.05 in non-PSL (P = 0.04). ISI quantity was 5.23 in PSL and 7.62 in non-PSL (P = 0.08), 5.83 in SMZL and 2.83 in other types of PSL (P = 0.12), 4.46 in non-splenic MZL and 8.21 in other types of non-PSL (P = 0.28). No difference in ISI quantity was found among the lymphoma subtypes, either in PSL (P = 0.74) or non-PSL (P = 0.3). The data demonstrate that ISI quantity in BM biopsies is not a reliable diagnostic parameter for SMZL. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|