Relationship between IgM Antibody to Human Cytomegalovirus, Virus Load, Donor and Recipient Serostatus, and Administration of Methylprednisolone as Risk Factors for Cytomegalovirus Disease after Liver Transplantation
| Autor: | M. P. Landini, Ak Burroughs, Keith Rolles, J. Wise, Gregory T. Maine, Tiziana Lazzarotto, Vincent C. Emery, Caroline A. Sabin, Susan Brojanac, A. V. Cope |
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| Rok vydání: | 2000 |
| Předmět: |
Human cytomegalovirus
Time Factors viruses medicine.medical_treatment Anti-Inflammatory Agents Congenital cytomegalovirus infection Cytomegalovirus Biology Liver transplantation Antibodies Viral Methylprednisolone Polymerase Chain Reaction Cohort Studies Postoperative Complications Risk Factors medicine Humans Immunology and Allergy Serologic Tests Retrospective Studies Immunoassay Hepatitis virus diseases Retrospective cohort study Viral Load medicine.disease Virology Tissue Donors Liver Transplantation Transplantation Infectious Diseases Immunoglobulin M Cytomegalovirus Infections DNA Viral Multivariate Analysis Immunology Disease Progression biology.protein Regression Analysis Viral load |
| Zdroj: | The Journal of Infectious Diseases. 182:1610-1615 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1086/317636 |
| Popis: | A retrospective study was performed on a selected cohort of 40 liver transplant recipients derived from the previous prospective follow-up of 162 liver transplant patients. The criterion for selection of this cohort was the presence of human cytomegalovirus (HCMV) DNAemia after transplantation, as determined by qualitative polymerase chain reaction (PCR), These 40 patients were followed longitudinally by quantitative PCR and by the new recombinant antigen-based AxSYM immunoassay for IgM to HCMV, The detection of IgM to CMV after transplantation was significantly associated with the development of HCMV disease in patients who had evidence of active HCMV replication in the blood by PCR (P = .01), On the basis of multivariate logistic regression analyses, the maximum titer of IgM detected after transplantation was a risk factor that was independent of augmented methylprednisolone and donor seropositivity, However, in multivariate analyses, elevated virus load continued to be the predominant risk factor for progression to HCMV disease. |
| Databáze: | OpenAIRE |
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