Variability of reproductive history across the Swiss SAPALDIA cohort--patterns and main determinants
| Autor: | Nicole Probst-Hensch, Sapaldia-Team, Margaret Gerbase, Christian Schindler, Elisabeth Zemp, Michael C. Constanza, Julia Dratva, Ursula Ackermann-Liebrich, Michael Constanza, Thierry Rochat, Patricia Staedele |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Aging medicine.medical_specialty Physiology Epidemiology media_common.quotation_subject Total fertility rate Population Fertility Kaplan-Meier Estimate Cohort Studies Pregnancy Genetics medicine Humans Age of Onset education Birth Rate media_common Aged Proportional Hazards Models Menarche education.field_of_study business.industry Smoking Public Health Environmental and Occupational Health Middle Aged medicine.disease Health Surveys Menopause Parity Cohort Population study Female Topography Medical business Switzerland Demography |
| Zdroj: | Annals of human biology. 34(4) |
| ISSN: | 0301-4460 |
| Popis: | Reproductive characteristics play an aetiological role for many diseases, including reproductive cancers. They have been shown to vary internationally and nationally, but have not yet been described for the whole Swiss population.The study investigated the variability of reproductive characteristics, their patterns, and main determinants across a population-based female study population in Switzerland.Reproductive characteristics obtained from 3119 women (28-72 years) participating in the SAPALDIA cohort survey in 2001-2003 are described across birth cohorts, study areas, language regions, and levels of urbanization. Determinants of age at menopause were analysed by Cox regression.Reported median age at menarche was 13 years and median age at natural menopause was 52 years. The prevalence of nulliparity was 27%, and the fertility rate 1.6. Across birth cohorts there was a decline of menarcheal age and fertility rates, and an increase of nulliparity and age at last pregnancy. All characteristics varied across study areas, language regions, and levels of urbanization. Smoking, parity, and physical exercise were stronger predictors of earlier (52 years) than older (52 years) menopausal age.Reproductive events show secular and geographic variation within Switzerland. Smoking, parity and physical activity significantly predict age at natural menopause, particularly before age 52. The secular trend of earlier menarche and increased nulliparity may result in a higher risk of reproductive cancers in younger generations. |
| Databáze: | OpenAIRE |
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