ANTI-B1 MONOCLONAL ANTIBODY AND COMPLEMENT TREATMENT IN AUTOLOGOUS BONE-MARROW TRANSPLANTATION FOR RELAPSED B-CELL NON-HODGKIN'S LYMPHOMA
| Autor: | Samuel Hellman, George P. Canellos, Leslie E. Botnick, Robert W. Finberg, Stuart F. Schlossman, Tak Takvorian, Robert C. Bast, Lee M. Nadler |
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| Rok vydání: | 1984 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Lymphoma medicine.drug_class medicine.medical_treatment Monoclonal antibody Transplantation Autologous Gastroenterology Recurrence Internal medicine medicine Humans B cell Bone Marrow Transplantation B-Lymphocytes Chemotherapy business.industry Antibodies Monoclonal Complement System Proteins General Medicine Middle Aged medicine.disease Combined Modality Therapy Non-Hodgkin's lymphoma Transplantation medicine.anatomical_structure Female Bone marrow business Chemoradiotherapy |
| Zdroj: | The Lancet. 324:427-431 |
| ISSN: | 0140-6736 |
| Popis: | Eight patients with relapsed B-cell non-Hodgkin's lymphoma were treated with intensive chemoradiotherapy and reconstituted with autologous bone marrow rendered free of tumour cells by the B-cell-specific monoclonal antibody anti-B 1 and complement. Before the autologous marrow transplantation patients were induced with chemotherapy, radiotherapy, or both, into a minimum disease state with less than 5% bone-marrow involvement with tumour. All patients treated achieved a complete clinical response and had stable haematological engraftment by 8 weeks. No significant acute or chronic toxic effects have occurred. B cells could be detected by 2 months after transplantation and normal immunoglobulin levels were achieved by 6 months. Six of eight patients are disease free in unmaintained remission more than 20, 19, 10, 8, 5, and 3 months after transplantation. |
| Databáze: | OpenAIRE |
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