Associations between intake of calcium, magnesium and phosphorus and risk of pancreatic cancer: a population-based, case–control study in Minnesota
| Autor: | Yunpeng Yu, Anna E. Prizment, Jianjun Zhang, Michael K. Reger, Margaret Hoyt, Haocheng Nan, Hao Fan, Kristin E. Anderson |
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| Rok vydání: | 2021 |
| Předmět: |
Minnesota
Population Medicine (miscellaneous) Physiology chemistry.chemical_element Calcium Logistic regression 03 medical and health sciences 0302 clinical medicine Nutrient Pancreatic cancer medicine Humans Magnesium 030212 general & internal medicine education Minerals education.field_of_study Nutrition and Dietetics business.industry Phosphorus Confounding Case-control study medicine.disease Diet Calcium Dietary Pancreatic Neoplasms chemistry Case-Control Studies 030220 oncology & carcinogenesis business |
| Zdroj: | British Journal of Nutrition. 126:1549-1557 |
| ISSN: | 1475-2662 0007-1145 |
| DOI: | 10.1017/s0007114521000283 |
| Popis: | Experimental studies suggest that abnormal levels of Ca, Mg and phosphorus are implicated in pancreatic carcinogenesis. We investigated the associations between intakes of these minerals and the risk of pancreatic cancer in a case-control study conducted in 1994–1998. Cases of pancreatic cancer (n 150) were recruited from all hospitals in the metropolitan area of the Twin Cities and Mayo Clinic, Minnesota. Controls (n 459) were randomly selected from the general population and frequency matched to cases by age, sex and race. All dietary variables were adjusted for energy intake using the residual method prior to data analysis. Logistic regression was performed to evaluate the associations between intake of three nutrients examined and the risk of pancreatic cancer. Total intake of Ca (936 v. 1026 mg/d) and dietary intake of Mg (315 v. 331 mg/d) and phosphorus (1350 v. 1402 mg/d) were significantly lower in cases than in controls. After adjustment for confounders, there were not significant associations of total and dietary intakes of Ca, Mg and phosphorus with the risk of pancreatic cancer. In addition, no significant interactions exist between intakes of these minerals and total fat on pancreatic cancer risk. In conclusion, the present study does not suggest that intakes of Ca, Mg and phosphorus were significantly associated with the risk of pancreatic cancer. |
| Databáze: | OpenAIRE |
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