Computing Arithmetic Functions Using Immobilised Enzymatic Reaction Networks

Autor:	Nikita M. Ivanov, Mathieu G. Baltussen, Cristina Lía Fernández Regueiro, Max T. G. M. Derks, Wilhelm T. S. Huck
Rok vydání:	2022
Předmět:	Spectroscopy and Catalysis General Chemistry General Medicine Catalysis Physical Organic Chemistry
Zdroj:	Angewandte Chemie. International Edition, 62, 7, pp. 1-7 Angewandte Chemie. International Edition, 62, 1-7
ISSN:	1521-3773 1433-7851
Popis:	Living systems use enzymatic reaction networks to process biochemical information and make decisions in response to external or internal stimuli. Here, we present a modular and reusable platform for molecular information processing using enzymes immobilised in hydrogel beads and compartmentalised in a continuous stirred tank reactor. We demonstrate how this setup allows us to perform simple arithmetic operations, such as addition, subtraction and multiplication, using various concentrations of substrates or inhibitors as inputs and the production of a fluorescent molecule as the readout.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30de1f9540e0b28e925a9b15daa9950c https://pubmed.ncbi.nlm.nih.gov/36562219 Zobrazit plný text záznamu Plný text