Reference intervals for glucose, beta-cell polypeptides, and counterregulatory factors during prolonged fasting
| Autor: | Henning Beck-Nielsen, C. Skjærbæk, Ole Koldkjær, Mette Wildner-Christensen, Kurt Højlund, Jens J. Holst, Ole Eshøj, Dorte Møller Jensen |
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| Předmět: |
Counterregulatory hormone
Adult Blood Glucose Male medicine.medical_specialty Epinephrine Hydrocortisone Physiology Endocrinology Diabetes and Metabolism Cell Serum albumin Biology Hypoglycemia Fatty Acids Nonesterified Glucagon Body Mass Index Norepinephrine Sex Factors Reference Values Physiology (medical) Internal medicine Hyperinsulinism medicine Humans Insulin Pancreatic hormone Serum Albumin Aged B-Lymphocytes C-Peptide Human Growth Hormone Fasting Middle Aged medicine.disease medicine.anatomical_structure Endocrinology Chemistry Clinical biology.protein Female Peptides Glucocorticoid medicine.drug Proinsulin |
| Zdroj: | Europe PubMed Central University of Southern Denmark Højlund, K, Wildner-Christensen, M, Eshøj, O, Skjaerbaek, C, Holst, J J, Koldkjaer, O, Møller Jensen, D & Beck-Nielsen, H 2001, ' Reference intervals for glucose, beta-cell polypeptides and counterregulatory factors during prolonged fasting ', American Journal of Physiology: Endocrinology and Metabolism, vol. 280, no. 1, pp. E50-E58 . Scopus-Elsevier CIÊNCIAVITAE |
| Popis: | Udgivelsesdato: 2001-Jan To establish reference intervals for the pancreatic beta-cell response and the counterregulatory hormone response to prolonged fasting, we studied 33 healthy subjects (16 males, 17 females) during a 72-h fast. Glucose, insulin, C-peptide, and proinsulin levels decreased (P < 0.001), and the levels of counterregulatory factors increased during the fast [P < 0.05; glucagon and free fatty acids (FFA) with a linear increase and epinephrine, norepinephrine, and cortisol with a clear underlying circadian rhythm]. Growth hormone secretion increased from the first to third day of fasting (P < 0.05) but actually decreased from the second to third day of fasting (P = 0.03). Males had higher glucose and glucagon levels and lower FFA levels during the fast (P < 0.05), whereas no effect of gender on beta-cell polypeptides was observed. A high body mass index resulted in higher insulin and C-peptide levels during the fast (P < 0.05). In conclusion, we have provided reference intervals for glucoregulatory factors during a 72-h fast. We observed a diminished beta-cell response concomitant with an increased secretion of counterregulatory hormones. These results should be of clinical and scientific value in the investigation of hypoglycemic disorders. |
| Databáze: | OpenAIRE |
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