Lily bulbs' polyphenols extract ameliorates oxidative stress and lipid accumulation in vitro and in vivo
| Autor: | Cuicui Chen, Yaoyao Hui, Changhai Jin, Ying Liu, Wangjing Xie, Juan Kan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
030309 nutrition & dietetics Pharmacology medicine.disease_cause Diet High-Fat Plant Roots 03 medical and health sciences Mice 0404 agricultural biotechnology Lipid oxidation In vivo medicine Lipolysis Animals Humans PPAR alpha chemistry.chemical_classification 0303 health sciences Reactive oxygen species Mice Inbred ICR Nutrition and Dietetics Chemistry Plant Extracts Polyphenols Lipid metabolism 04 agricultural and veterinary sciences Hep G2 Cells medicine.disease Lipid Metabolism 040401 food science Mitochondria Fatty Liver Oxidative Stress Polyphenol Lilium Steatosis Reactive Oxygen Species Sterol Regulatory Element Binding Protein 1 Agronomy and Crop Science Oxidative stress Food Science Biotechnology |
| Zdroj: | Journal of the science of food and agricultureREFERENCES. 101(12) |
| ISSN: | 1097-0010 |
| Popis: | BACKGROUND Polyphenols have the potential to reduce the risk of many metabolic disorders. Lily bulbs are rich in polyphenols; however, their effects on lipid metabolism remain unclear. This study aimed to explore the effects of lily bulbs' polyphenols (LBPs) on oxidative stress and lipid metabolism. RESULTS A total of 14 polyphenolic compounds in LBPs were identified by high-performance liquid chromatography equipped with diode-array detection mass spectrometry. Total phenolic compound in LBPs was 53.76 ± 1.12 g kg-1 dry weight. In cellular experiments, LBPs attenuated the disruption of mitochondrial membrane potential, impeded reactive oxygen species production, alleviated oxidative stress, and reduced lipid accumulation in oleic acid induced HepG2 cells. In in vivo studies, LBPs significantly inhibited body weight gain, reduced lipid levels in serum and liver, and improved oxidative damage in a dose-dependent manner in mice fed a high-fat diet. Moreover, LBPs ameliorated hepatic steatosis and suppressed the expression of hepatic-lipogenesis-related genes (SREBP-1c, FAS, ACC1, and SCD-1) and promoted lipolysis genes (SRB1 and HL) and lipid oxidation genes (PPARα and CPT-1) in mice fed a high-fat diet. CONCLUSION It was concluded that LBPs are a potential complementary therapeutic alternative in the development of functional foods to curb obesity and obesity-related diseases, such as metabolic syndrome. © 2021 Society of Chemical Industry. |
| Databáze: | OpenAIRE |
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