Cyclosporin A in atopic dermatitis: therapeutic resonse is disociated form effects on allergic reactons
| Autor: | J.M. Marks, C. S. Munro, Sam Shuster, B M Daly, Peter S. Friedmann, E. M. Higgins |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
Hypersensitivity Immediate Male Allergy medicine.medical_specialty Adolescent medicine.medical_treatment Cyclosporins Dermatology Dermatitis Atopic Immunopathology Cyclosporin a medicine Humans Adverse effect Skin Skin Tests House dust mite Chemotherapy biology business.industry Therapeutic effect Atopic dermatitis Immunoglobulin E Middle Aged medicine.disease biology.organism_classification Immunology Female business |
| Zdroj: | British Journal of Dermatology. 124:43-48 |
| ISSN: | 1365-2133 0007-0963 |
| DOI: | 10.1111/j.1365-2133.1991.tb03280.x |
| Popis: | Fourteen patients with severe chronic atopic dermatitis were treated with cyclosporin A (CyA, Sandimmun; 5 mg/kg/day) for 7-16 weeks. All showed a marked clinical improvement and half could omit topical corticosteroid treatment during therapy. Adverse effects were minor, but two patients relapsed despite continued treatment. In the others, the disease recurred soon after stopping CyA. Serum IgE levels and prick-test responses were unchanged by CyA. Immediate and late-phase cutaneous responses to intradermal house dust mite antigen (HDM) were significantly increased during treatment; but a delayed response, present at 24 and 48 h, was unaffected. Four of six patients challenged with HDM patch tests to tape-stripped skin during treatment showed eczematous reactions at 48 h. Thus, cyclosporin A has a powerful therapeutic effect in atopic dermatitis but does not reduce allergic responses to inhalant antigens. |
| Databáze: | OpenAIRE |
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