Characterization of the Effects of the Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), on Severe Gestational Diabetes Mellitus in Rats
| Autor: | Bianca Hessel Maschio, Marli Gerenutti, Lucas Silva Rodrigues, Carolina Alves dos Santos, Sara Rosicler Vieira Spim, Bianca Carvalho Gentil, Erika Leão Ajala Caetano, Leticia F. Laurino, Denise Grotto, Angela Faustino Jozala |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
endocrine system diseases medicine.medical_treatment Shiitake Mushrooms Administration Oral Pharmacology Applied Microbiology and Biotechnology Diabetes Mellitus Experimental 03 medical and health sciences Pregnancy Diabetes mellitus Drug Discovery medicine Animals Saline Mushroom 030109 nutrition & dietetics biology business.industry nutritional and metabolic diseases medicine.disease Streptozotocin biology.organism_classification Diet Rats Gestational diabetes Diabetes Gestational Disease Models Animal Treatment Outcome Dietary Supplements Lentinus Gestation Female business medicine.drug |
| Zdroj: | International Journal of Medicinal Mushrooms. 19:991-1000 |
| ISSN: | 1521-9437 |
| DOI: | 10.1615/intjmedmushrooms.2017024498 |
| Popis: | This study evaluated the protective effect of Lentinus edodes in rats with streptozotocin-induced gestational diabetes mellitus (STZ-GDM) when administered orally. The rats received from the 1st to the 19th day of gestation daily doses of 100 or 200 mg/kg of lyophilized and reconstituted L. edodes; the animals in the saline control group and diabetic control group received a saline solution (DS). Gestational diabetes mellitus was induced by streptozotocin (80 mg/kg, administered intraperitoneally) on the fourth day of pregnancy; blood glucose > 180 mg/dL was considered to indicate STZ-GDM. L. edodes reduced catalase in plasma. We also observed reduced glucose in plasma, urea, triglycerides, and aspartate aminotransferase. There was a decrease in preimplantation loss when compared with the DS group. The doses of L. edodes used here had a protective effect on the preimplantation parameters in STZGDM. However, the mushroom was not able to reverse the deleterious effects caused by streptozotocin throughout the evolution of pregnancy. |
| Databáze: | OpenAIRE |
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