Top 10 priorities for future infertility research: an international consensus development study
Autor: | J.M.N. Duffy, G.D. Adamson, E. Benson, S. Bhattacharya, M. Bofill, K. Brian, B. Collura, C. Curtis, J.L.H. Evers, R.G. Farquharson, A. Fincham, S. Franik, L.C. Giudice, E. Glanville, M. Hickey, A.W. Horne, M.L. Hull, N.P. Johnson, V. Jordan, Y. Khalaf, J.M.L. Knijnenburg, R.S. Legro, S. Lensen, J. MacKenzie, D. Mavrelos, B.W. Mol, D.E. Morbeck, H. Nagels, E.H.Y. Ng, C. Niederberger, A.S. Otter, L. Puscasiu, S. Rautakallio-Hokkanen, L. Sadler, I. Sarris, M. Showell, J. Stewart, A. Strandell, C. Strawbridge, A. Vail, M. van Wely, M. Vercoe, N.L. Vuong, A.Y. Wang, R. Wang, J. Wilkinson, K. Wong, T.Y. Wong, C.M. Farquhar, Hisham AlAhwany, Ofra Balaban, Yusuf Beebeejaun, Jacky Boivin, Jan J.A. Bosteels, Arianna D’Angelo, Leona F. Dann, Christopher J. De Jonge, Elyce du Mez, Rui A. Ferriani, Marie-Odile Gerval, Lynda J. Gingel, Ellen M. Greenblatt, Geraldine Hartshorne, Charlie Helliwell, Charlotte Helliwell, Lynda J. Hughes, Junyoung Jo, Jelena Jovanović, Ludwig Kiesel, Chumnan Kietpeerakool, Elena Kostova, Tansu Kucuk, Robyn L. Lawrence, Nicole Lee, Katy E. Lindemann, Olabisi M. Loto, Peter J. Lutjen, Michelle MacKinven, Mariano Mascarenhas, Helen McLaughlin, David J. Mills, Selma M. Mourad, Linh K. Nguyen, Robert J. Norman, Maja Olic, Kristine L. Overfield, Maria Parker-Harris, David G. Ramos, Aleksandra Rendulic, Sjoerd Repping, Roberta Rizzo, Pietro Salacone, Catherine H. Saunders, Rinku Sengupta, Ioannis A. Sfontouris, Natalie R. Silverman, Helen L. Torrance, Eleonora P. Uphoff, Sarah A. Wakeman, Tewes Wischmann, Bryan J. Woodward, Mohamed A. Youssef |
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Přispěvatelé: | RS: GROW - R4 - Reproductive and Perinatal Medicine, Obstetrics and Gynaecology, Center for Reproductive Medicine, APH - Methodology, APH - Personalized Medicine, ARD - Amsterdam Reproduction and Development |
Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Male
Delphi Technique International Cooperation WASTE Reproductive technology GUIDELINES State Medicine 0302 clinical medicine Pregnancy Interim Nominal group technique Health care 030212 general & internal medicine media_common education.field_of_study 030219 obstetrics & reproductive medicine Rehabilitation Obstetrics and Gynecology Fertility clinic Systematic review research priorities Practice Guidelines as Topic Female HEALTH and research priorities infertility modified Delphi method reproductive medicine Consensus media_common.quotation_subject Population education Fertility Consensus science methods 03 medical and health sciences Ovulation Induction Political science MANAGEMENT Humans modified Nominal Group Technique Obstetrics & Reproductive Medicine Fertility Clinics Medical education business.industry Research 11 Medical and Health Sciences 16 Studies in Human Society Original Articles AcademicSubjects/MED00905 CORE OUTCOME SET Infertility FIBROIDS business New Zealand |
Zdroj: | Human Reproduction, 35(12), 2715-2724. Oxford University Press Fertility and sterility, 115(1), 180-190. Elsevier Inc. Human Reproduction (Oxford, England) Wilkinson, J & Vail, A 2020, ' Top 10 priorities for future infertility research: an international consensus development study. ', Human reproduction (Oxford, England) . https://doi.org/10.1093/humrep/deaa242 Human reproduction (Oxford, England), 35(12), 2715-2724. Oxford University Press Fertility and Sterility, 115(1), 180-190. Elsevier Science |
ISSN: | 0268-1161 0015-0282 |
Popis: | STUDY QUESTION Can the priorities for future research in infertility be identified? SUMMARY ANSWER The top 10 research priorities for the four areas of male infertility, female and unexplained infertility, medically assisted reproduction and ethics, access and organization of care for people with fertility problems were identified. WHAT IS KNOWN ALREADY Many fundamental questions regarding the prevention, management and consequences of infertility remain unanswered. This is a barrier to improving the care received by those people with fertility problems. STUDY DESIGN, SIZE, DURATION Potential research questions were collated from an initial international survey, a systematic review of clinical practice guidelines and Cochrane systematic reviews. A rationalized list of confirmed research uncertainties was prioritized in an interim international survey. Prioritized research uncertainties were discussed during a consensus development meeting. Using a formal consensus development method, the modified nominal group technique, diverse stakeholders identified the top 10 research priorities for each of the categories male infertility, female and unexplained infertility, medically assisted reproduction and ethics, access and organization of care. PARTICIPANTS/MATERIALS, SETTING, METHODS Healthcare professionals, people with fertility problems and others (healthcare funders, healthcare providers, healthcare regulators, research funding bodies and researchers) were brought together in an open and transparent process using formal consensus methods advocated by the James Lind Alliance. MAIN RESULTS AND THE ROLE OF CHANCE The initial survey was completed by 388 participants from 40 countries, and 423 potential research questions were submitted. Fourteen clinical practice guidelines and 162 Cochrane systematic reviews identified a further 236 potential research questions. A rationalized list of 231 confirmed research uncertainties was entered into an interim prioritization survey completed by 317 respondents from 43 countries. The top 10 research priorities for each of the four categories male infertility, female and unexplained infertility (including age-related infertility, ovarian cysts, uterine cavity abnormalities and tubal factor infertility), medically assisted reproduction (including ovarian stimulation, IUI and IVF) and ethics, access and organization of care were identified during a consensus development meeting involving 41 participants from 11 countries. These research priorities were diverse and seek answers to questions regarding prevention, treatment and the longer-term impact of infertility. They highlight the importance of pursuing research which has often been overlooked, including addressing the emotional and psychological impact of infertility, improving access to fertility treatment, particularly in lower resource settings and securing appropriate regulation. Addressing these priorities will require diverse research methodologies, including laboratory-based science, qualitative and quantitative research and population science. LIMITATIONS, REASONS FOR CAUTION We used consensus development methods, which have inherent limitations, including the representativeness of the participant sample, methodological decisions informed by professional judgment and arbitrary consensus definitions. WIDER IMPLICATIONS OF THE FINDINGS We anticipate that identified research priorities, developed to specifically highlight the most pressing clinical needs as perceived by healthcare professionals, people with fertility problems and others, will help research funding organizations and researchers to develop their future research agenda. STUDY FUNDING/COMPETING INTEREST(S) The study was funded by the Auckland Medical Research Foundation, Catalyst Fund, Royal Society of New Zealand and Maurice and Phyllis Paykel Trust. G.D.A. reports research sponsorship from Abbott, personal fees from Abbott and LabCorp, a financial interest in Advanced Reproductive Care, committee membership of the FIGO Committee on Reproductive Medicine, International Committee for Monitoring Assisted Reproductive Technologies, International Federation of Fertility Societies and World Endometriosis Research Foundation, and research sponsorship of the International Committee for Monitoring Assisted Reproductive Technologies from Abbott and Ferring. Siladitya Bhattacharya reports being the Editor-in-Chief of Human Reproduction Open and editor for the Cochrane Gynaecology and Fertility Group. J.L.H.E. reports being the Editor Emeritus of Human Reproduction. A.W.H. reports research sponsorship from the Chief Scientist’s Office, Ferring, Medical Research Council, National Institute for Health Research and Wellbeing of Women and consultancy fees from AbbVie, Ferring, Nordic Pharma and Roche Diagnostics. M.L.H. reports grants from Merck, grants from Myovant, grants from Bayer, outside the submitted work and ownership in Embrace Fertility, a private fertility company. N.P.J. reports research sponsorship from AbbVie and Myovant Sciences and consultancy fees from Guerbet, Myovant Sciences, Roche Diagnostics and Vifor Pharma. J.M.L.K. reports research sponsorship from Ferring and Theramex. R.S.L. reports consultancy fees from AbbVie, Bayer, Ferring, Fractyl, Insud Pharma and Kindex and research sponsorship from Guerbet and Hass Avocado Board. B.W.M. reports consultancy fees from Guerbet, iGenomix, Merck, Merck KGaA and ObsEva. E.H.Y.N. reports research sponsorship from Merck. C.N. reports being the Co Editor-in-Chief of Fertility and Sterility and Section Editor of the Journal of Urology, research sponsorship from Ferring and retains a financial interest in NexHand. J.S. reports being employed by a National Health Service fertility clinic, consultancy fees from Merck for educational events, sponsorship to attend a fertility conference from Ferring and being a clinical subeditor of Human Fertility. A.S. reports consultancy fees from Guerbet. J.W. reports being a statistical editor for the Cochrane Gynaecology and Fertility Group. A.V. reports that he is a Statistical Editor of the Cochrane Gynaecology & Fertility Review Group and the journal Reproduction. His employing institution has received payment from Human Fertilisation and Embryology Authority for his advice on review of research evidence to inform their ‘traffic light’ system for infertility treatment ‘add-ons’. N.L.V. reports consultancy and conference fees from Ferring, Merck and Merck Sharp and Dohme. The remaining authors declare no competing interests in relation to the present work. All authors have completed the disclosure form. TRIAL REGISTRATION NUMBER N/A. |
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