Efficacy and Safety of Two Methadone Titration Methods for the Treatment of Cancer-Related Pain: The EQUIMETH2 Trial (Methadone for Cancer-Related Pain)
| Autor: | Eric Serra, B. Devalois, Marie-Pierre Berleur, B. Dang Vu, D. Mayeur, A. Simon, M. Montagne, D. Dupoiron, S. Laurent, Cyril Guillaumé, Danièle Lefebvre, Gisèle Chvetzoff, Fibra Tremellat, B. George, O. Dubroecq, Philippe Poulain, Shimsi Lefki, Alain Derniaux, N. Saffon, Marilène Filbet, P. Brillaxis |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Palliative care Context (language use) Kaplan-Meier Estimate 03 medical and health sciences 0302 clinical medicine 030202 anesthesiology Multicenter trial medicine Clinical endpoint Humans General Nursing Pain Measurement business.industry Breakthrough Pain Cancer Pain Middle Aged Analgesics Opioid Anesthesiology and Pain Medicine Nociception Treatment Outcome Opioid 030220 oncology & carcinogenesis Retreatment Physical therapy Female Neurology (clinical) Drug Overdose business Cancer pain Methadone medicine.drug Follow-Up Studies |
| Zdroj: | Journal of pain and symptom management. 52(5) |
| ISSN: | 1873-6513 |
| Popis: | In the European Association for Palliative Care recommendations for cancer pain management, there was no consensus regarding the indications, titration, or monitoring of methadone.This national, randomized, multicenter trial aimed to compare two methadone titration methods (stop-and-go vs. progressive) in patients with cancer-related pain who were inadequately relieved by or intolerant to Level 3 opioids.The primary end point was the rate of success/failure at Day 4, defined as pain relief (reduction of at least two points on the visual scale and a pain score5 for two consecutive days) and no overdose (Rudkin scale ≥3 and respiratory rate8/minute). The patients were followed for two months after enrollment.The cancer-related pain characteristics of the 146 patients were as follows: 16% were nociceptive, 85% experienced breakthrough pain, and 84% had mixed types of pain. The reasons for switching to methadone were a lack of efficacy that was either isolated (56%) or associated with intolerance (38%). Adequate pain relief was obtained in 80% of the patients (median of three days in both groups [P = 0.12]) and lasted until D56. The rate of success/failure was approximately 40% at Day 4 in both groups, with overdoses in 13% of the patients throughout the study. The two methods were considered equally easy to perform by nearly 60% of the clinicians.Methadone is an effective and sustainable second-line alternative opioid for the treatment of cancer-related pain. The methods of titration are comparable in terms of efficacy, safety, and ease of use. |
| Databáze: | OpenAIRE |
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