The efficacy of alpha-tocopherol in functional recovery of spinal cord injured rats: an experimental study
| Autor: | Sultan Al-Mubarak, Asirvatham Alwin Robert, M S I Al Jadid |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Time Factors Movement alpha-Tocopherol Neurological disorder Antioxidants Rats Sprague-Dawley Central nervous system disease chemistry.chemical_compound medicine Animals heterocyclic compounds Spinal cord injury Spinal Cord Injuries Behavior Animal Dose-Response Relationship Drug business.industry Body Weight food and beverages Recovery of Function General Medicine Functional recovery medicine.disease Spinal cord Rats Surgery Sprague dawley Disease Models Animal Dose–response relationship medicine.anatomical_structure Neurology chemistry Anesthesia Female lipids (amino acids peptides and proteins) Neurology (clinical) business |
| Zdroj: | Spinal Cord. 47:662-667 |
| ISSN: | 1476-5624 1362-4393 |
| DOI: | 10.1038/sc.2009.22 |
| Popis: | The objective of this study is to examine the effects of the alpha-tocopherol on rats with spinal cord injury (SCI).Research Center, Sultan Bin Abdulaziz Humanitarian City, Riyadh, Kingdom of Saudi Arabia.Female Sprague-Dawley rats weighing 180-220 g were anesthetized with chloral hydrate (450 mg kg(-1) body weight) by intraperitoneal injection and laminectomy was performed at the T 7-8 level leaving the dura intact. A compression plate (2.2 x 5.0 mm) was loaded with a weight of 35 g placed on the exposed cord for 5 min to create SCI. The subjects were divided into three groups of eight rats each. Group 1 served as control (SCI+saline); whereas groups 2 and 3 served as test groups, alpha-tocopherol was given orally in doses of 1000 mg kg(-1) body weight for group 2 and 2000 mg kg(-1) body weight for group 3, respectively. Daily activities were recorded in the activity cage for 14 days post-operatively.At day 1 (baseline, 24 h after the surgery), there was no significant difference between mean motor scores of all groups. After day 1, the three groups showed continuous improvement in motor score; such improvement was maintained throughout the duration of the study with different levels for each group. By the end of the study (day 14), groups 2 and 3 showed statistically significant improvement in the mean motor score compared with group 1 (P0.05). However, no significant difference was observed between test groups 2 and 3 by the end of the study.The results suggest that the administration of alpha-tocopherol may have reparative effects for SCI because of its antioxidant effect. |
| Databáze: | OpenAIRE |
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