The Effect of Features of the Metabolic Syndrome on Atherosclerotic Risk in Relatively Long-Surviving Patients with Type 1 Diabetes
| Autor: | Greg Distiller, Larry A. Distiller, Barry I. Joffe, Vanessa Brown |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Endocrinology Diabetes and Metabolism Carotid arteries Young Adult Risk Factors Internal medicine Diabetes mellitus Internal Medicine medicine Humans Survivors cardiovascular diseases Risk factor International diabetes federation Aged Metabolic Syndrome Type 1 diabetes business.industry nutritional and metabolic diseases Middle Aged Atherosclerosis medicine.disease Surgery Diabetes Mellitus Type 1 Intima-media thickness Cohort cardiovascular system Female Metabolic syndrome business Follow-Up Studies |
| Zdroj: | Metabolic Syndrome and Related Disorders. 8:539-543 |
| ISSN: | 1557-8518 1540-4196 |
| Popis: | Increasing numbers of patients with type 1 diabetes (T1DM) are developing features of the metabolic syndrome. The additional effect of this on the development of atherosclerosis, as inferred by the carotid artery intima media thickness (IMT), has not previously been assessed. The aim of this study was to assess the effect of features of the metabolic syndrome on carotid artery IMT in a cohort of long-surviving patients with T1DM.Long-surviving patients with T1DM attending the Centre for Diabetes and Endocrinology were assessed regarding their risk factor profile. All underwent measurement of carotid artery IMT. In all, 156 patients who had T1DM for more than 18 years had their carotid artery IMT measured. All had been attending the clinic for over 10 years, and past clinical and laboratory records were available.A total of 37 patients had metabolic syndrome according to the International Diabetes Federation (IDF) definition. Those with metabolic syndrome had a significantly increased carotid artery IMT (P = 0.003) compared to those without the syndrome. There was a significant relationship between the number of features of metabolic syndrome and increased atherosclerotic risk according to the carotid artery IMT (P = 0.01). A significant correlation was found between carotid artery IMT and both waist circumference (P 0.001) and insulin resistance (P = 0.005).In long-surviving patients with T1DM, those that develop metabolic syndrome are more likely to have thicker carotid artery IMT, and, by inference, be at higher risk of atherosclerosis and possibly cardiovascular disease. A linear relationship was present between both waist circumference and insulin resistance and carotid artery IMT. |
| Databáze: | OpenAIRE |
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