Inflammation and Aortic Stiffness: An Individual Participant Data Meta‐Analysis in Patients With Inflammatory Bowel Disease

Autor: Maria Cappello, Julien Blanco, Gaetano Inserra, Paolo Lentini, Antonino Tuttolomondo, Pasquale Fatuzzo, Pierre Boutouyrie, Stefania Rastelli, Stéphane Laurent, Antonio Granata, Kadir Ozturk, Antonio Pinto, Anna Licata, Calogero Cammà, Pietro Castellino, Eleni Theocharidou, Luca Zanoli
Přispěvatelé: Zanoli, L, Boutouyrie, P, Fantauzzo, P, Granata, A, Lentini, P, Ozturk, K, Cappello, M, Theocharidou, E, Tuttolomondo, A, Pinto, A, Camma, C, Licata, A, Blanco, J, Rastelli, S, Inserra, G, Castellino, P, Laurent, S
Rok vydání: 2017
Předmět:
medicine.medical_specialty
Settore MED/09 - Medicina Interna
pulse wave velocity
cardiovascular complications
Blood Sedimentation
Pulse Wave Analysis
030204 cardiovascular system & hematology
Standard score
Inflammatory bowel disease
Leukocyte Count
03 medical and health sciences
Vascular Stiffness
0302 clinical medicine
Crohn Disease
Risk Factors
Internal medicine
medicine
Humans
Arterial stiffness
Cardiovascular complications
Crohn's disease
Inflammation
Pulse wave velocity
Ulcerative colitis
Cardiology and Cardiovascular Medicine
030212 general & internal medicine
ulcerative colitis
Systematic Review and Meta‐Analysis
medicine.diagnostic_test
business.industry
Meta Analysis
inflammation
aortic stiffness
Prognosis
medicine.disease
Confidence interval
C-Reactive Protein
arterial stiffness
Cardiovascular Diseases
Meta-analysis
Erythrocyte sedimentation rate
Multivariate Analysis
Hypertension
Linear Models
Physical therapy
Colitis
Ulcerative
Inflammation Mediators
business
Biomarkers
Zdroj: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
ISSN: 2047-9980
4201-6053
DOI: 10.1161/jaha.117.007003
Popis: Background The recent finding that aortic pulse wave velocity ( aPWV ) is increased in patients with inflammatory bowel disease may explain why the cardiovascular risk is increased despite the low prevalence of traditional cardiovascular risk factors. We aimed to test whether inflammation is associated with aortic stiffening in this setting after adjustment for major confounders and to perform subgroup analyses. Methods and Results A systematic literature search for aPWV in inflammatory bowel disease was performed using PubMed, Scopus, Web of Science, and Google Scholar databases (last accessed May 7, 2017). Inclusion criterion was peer‐reviewed publications on clinical studies reporting original data. This study followed the Preferred Reporting Items for Systematic Review and Meta‐Analyses of individual participant data 2015 guidelines. Data were provided for 4 cohorts in 3 countries (151 participants with ulcerative colitis, 159 with Crohn's disease, and 227 control patients). Using aPWV , cohort‐specific z scores were calculated after log e ‐transform and combined in meta‐analysis to form pooled effects using a random‐effects model. Compared with controls, aPWV was increased in patients with Crohn's disease (mean difference 0.78 z score; 95% confidence interval, 0.56–1.00 z score [ P z score; 95% confidence interval, 0.52–0.97 z score [ P aPWV was associated with disease duration (years, β=0.05 z score; 95% confidence interval, 0.02–0.08 z score [ P z score; 95% confidence interval, 0.02–0.11 z score [ P =0.002]) but not with markers of acute inflammation (C‐reactive protein and erythrocyte sedimentation rate), cardiovascular risk factors, and therapy. Conclusions The increased aPWV reported in patients with inflammatory bowel disease is associated with inflammation. Clinical Trial Registration URL : http://www.crd.york.ac.uk . Unique identifier: PROSPERO 2016: CRD 42016053070.
Databáze: OpenAIRE
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