Succinct synthesis of saturated hydroxy fatty acids and:In vitro evaluation of all hydroxylauric acids on FFA1, FFA4 and GPR84
| Autor: | Mads H. Kaspersen, Julia Dunlop, Laura Jenkins, Trond Ulven, Graeme Milligan |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Pharmacology
chemistry.chemical_classification 010405 organic chemistry Stereochemistry Organic Chemistry Hydroxy group Pharmaceutical Science Fatty acid 010402 general chemistry 01 natural sciences Biochemistry In vitro 0104 chemical sciences chemistry.chemical_compound chemistry Drug Discovery Structural isomer GPR84 Molecular Medicine Organic chemistry Polyunsaturated fatty acid |
| Zdroj: | Kaspersen, M H, Jenkins, L, Dunlop, J, Milligan, G & Ulven, T 2017, ' Succinct synthesis of saturated hydroxy fatty acids and : In vitro evaluation of all hydroxylauric acids on FFA1, FFA4 and GPR84 ', MedChemComm, vol. 8, no. 6, pp. 1360-1365 . https://doi.org/10.1039/c7md00130d |
| Popis: | Saturated hydroxy fatty acids make up a class of underexplored lipids with potentially interesting biological activities. We report a succinct and general synthetic route to saturated hydroxy fatty acids hydroxylated at position 6 or higher, and exemplify this with the synthesis of hydroxylauric acids. All regioisomers of hydroxylauric acids were tested on free fatty acid receptors FFA1, FFA4 and GPR84. The results show that the introduction of a hydroxy group and its position have a high impact on receptor activity. |
| Databáze: | OpenAIRE |
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