Chitosan nanoparticles facilitate improved intestinal permeation and oral pharmacokinetics of the mast cell stabiliser cromoglycate

Autor: Paul Joyce, Anthony Wignall, Karl Peressin, Leah Wright, Desmond B Williams, Clive A. Prestidge
Přispěvatelé: Joyce, Paul, Wignall, Anthony, Peressin, Karl, Wright, Leah, Williams, Desmond B, Prestidge, Clive A
Rok vydání: 2022
Předmět:
Zdroj: International Journal of Pharmaceutics. 612:121382
ISSN: 0378-5173
DOI: 10.1016/j.ijpharm.2021.121382
Popis: Refereed/Peer-reviewed Cromoglycate is a mast cell stabiliser typically administered via inhalation or intranasally for the treatment of allergy-based respiratory issues. Oral dosing of cromoglycate remains challenging due to its high solubility but low permeability across epithelial membranes in the gastrointestinal tract: effective formulation strategies are clearly needed. Here, we investigate and preclinically develop chitosan-cromoglycate complexes and associated nano/microparticle formulations with muco-adhesive and permeation enhancing capabilities to overcome the biopharmaceutical challenges for oral dosing. The synthesized complexes were optimized with respect to chitosan grade, particle size, and drug loading and demonstrated up to a 9.3-fold enhancement in permeability across a Caco-2 monolayer for chitosan-cromoglycate particles, compared to the pure drug. This increased intestinal permeability led to improved pharmacokinetic performance of cromoglycate, e.g. up to 1.82-fold increase in relative oral bioavailability when dosed to Sprague-Dawley rats in a fasted state. These findings confirm the potential for chitosan particles to serve as an effective oral delivery vehicle for cromoglycate, with additional formulation optimization presenting the opportunity to reduce dosing frequency for treatment of allergy-based respiratory ailments.
Databáze: OpenAIRE
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