Evaluation of Changes in the Expression Pattern of EDIL3 in Different Grades of Endometrial Cancer
| Autor: | Konrad Dziobek, Marcin Oplawski, Ewa Leśniak, Beniamin Grabarek, Iwona Adwent, Dariusz Boroń, Nikola Zmarzły, Barbara Tomala, Piotr Januszyk, Dariusz Dąbruś |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Angiogenesis Pharmaceutical Science Complementary diagnostic marker Article Extracellular matrix 03 medical and health sciences EDIL3 0302 clinical medicine Endometrial cancer Expression pattern Internal medicine Biomarkers Tumor Tumor Microenvironment medicine Humans Epithelial–mesenchymal transition Tumor microenvironment Neovascularization Pathologic TGFβs business.industry Calcium-Binding Proteins Cell Differentiation Middle Aged Epithelial-mesenchymal transition medicine.disease Immunohistochemistry Personalized medicine Endometrial Neoplasms 030104 developmental biology Case-Control Studies 030220 oncology & carcinogenesis Female Neoplasm Grading Carrier Proteins business Cell Adhesion Molecules Biotechnology |
| Zdroj: | Current Pharmaceutical Biotechnology |
| ISSN: | 1389-2010 |
| DOI: | 10.2174/1389201020666190408112822 |
| Popis: | Background:EDIL3 is an extracellular matrix protein that plays a key role in angiogenesis. Changes in the pattern of its expression also affect cellular processes and the tumor microenvironment. Elevated level of EDIL3 is considered an unfavorable prognostic marker of survival.Objective:The aim of this study was to evaluate the changes in EDIL3 expression in endometrial cancer at various degrees of its differentiation (G1-G3) and to discuss its potential role as a molecular diagnostic marker and therapeutic target.Methods:The study group consisted of 45 patients with endometrial cancer: G1, 17; G2, 15; G3, 13. The control group (C) included 15 patients without neoplastic changes. The expression of EDIL3 was assessed using immunohistochemistry. Statistical analysis was performed using the Statistica 12 PL software (pResults:Analysis of EDIL3 expression showed that the average optical density of the reaction product in G1 reached 130% of the control, while the values in G2 and G3 were 153% and 158%, respectively. Regardless of the endometrial cancer grade, an increase in EDIL3 level was observed compared to the control.Conclusion:In our study, we demonstrated overexpression of EDIL3 protein in endometrial cancer. Differences in expression between degrees of tumor differentiation suggest the potential of using changes in EDIL3 level as a new complementary diagnostic marker and target for anti-angiogenic therapy. |
| Databáze: | OpenAIRE |
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