CD8+ and CD4+ tumour infiltrating lymphocytes in relation to human papillomavirus status and clinical outcome in tonsillar and base of tongue squamous cell carcinoma
| Autor: | Anders Näsman, Nikolaos Tertipis, Lars Sivars, Torbjörn Ramqvist, Cecilia Nordfors, Linnea Haeggblom, Tina Dalianis, Linda Marklund, Andreas Ährlund-Richter, Tommy Nyberg, Nathalie Grün, Eva Munck-Wikland, Juan Du |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male Cancer Research medicine.medical_specialty Formalin fixed paraffin embedded Tongue squamous cell carcinoma Tonsillar Neoplasms Pilot Projects Biology CD8-Positive T-Lymphocytes Gastroenterology Lymphocytes Tumor-Infiltrating Internal medicine medicine Carcinoma Biomarkers Tumor Humans Human papillomavirus Papillomaviridae Aged Aged 80 and over Squamous Cell Carcinoma of Head and Neck Papillomavirus Infections Middle Aged medicine.disease Tongue Neoplasms Log-rank test Hpv testing Treatment Outcome Oncology Head and Neck Neoplasms Cancer research Carcinoma Squamous Cell Immunohistochemistry Female CD8 |
| Zdroj: | European journal of cancer (Oxford, England : 1990). 49(11) |
| ISSN: | 1879-0852 |
| Popis: | Patients with human papillomavirus (HPV) positive tonsillar and base of tongue squamous cell carcinoma (TSCC and BOTSCC, respectively) have a better clinical outcome than those with HPV negative tumours, irrespective of treatment. However, to better individualise treatment, additional biomarkers are needed together with HPV status. In a pilot study, we showed that high numbers of CD8(+) tumour infiltrating lymphocytes (TILs) in HPVDNA+ p16(INK4a+) TSCC indicated a better outcome. Here this study was extended. Totally 203 TSCC and 77 BOTSCC formalin fixed paraffin embedded tumour biopsies, earlier tested for HPV DNA (79% HPVDNA+) and p16(INK4a) from patients treated with curative intention, were analysed for CD8(+) and CD4(+) TILs by immunohistochemistry. Data obtained for 275 patients were correlated to HPVDNA and p16(INK4a) status, overall survival (OS) and disease free survival (DFS). In both HPVDNA+ and HPVDNA+ p16(INK4a+) tumours higher CD8(+) TIL counts correlated to a better 3-year OS (logrank test, both p |
| Databáze: | OpenAIRE |
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