Incompletely resected advanced squamous cell carcinoma of the head and neck: The effectiveness of adjuvant vs. salvage radiotherapy
| Autor: | Joel Weber, James P. Neifeld, Aristides Sismanis, Rupert Schmidt-Ullrich, David T. Huang, Christopher R. Johnson |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Postoperative irradiation medicine Humans Radiology Nuclear Medicine and imaging Basal cell In patient Stage (cooking) Head and neck Aged Retrospective Studies Aged 80 and over Salvage Therapy business.industry Hematology Middle Aged Combined Modality Therapy Surgery Survival Rate Radiation therapy Oncology Head and Neck Neoplasms Salvage radiotherapy Carcinoma Squamous Cell Female Neoplasm Recurrence Local business Adjuvant Follow-Up Studies |
| Zdroj: | Radiotherapy and Oncology. 24:87-93 |
| ISSN: | 0167-8140 |
| DOI: | 10.1016/0167-8140(92)90284-2 |
| Popis: | Between 1982 and 1988, 441 patients were treated at the Medical College of Virginia for AJC Stage III and IV squamous cell carcinoma of the head and neck. We report here on 84 patients whose tumors were incompletely resected based on histopathological margins of 1 mm or less. Of these 84 patients, 49 were treated with surgery alone and 35 received immediate postoperative irradiation to doses of 50–70 Gy. The two patient groups are comparable with respect to stage of disease, age, male/female and racial ratios. This retrospective analysis, based on follow-up of 24–110 months, gives actuarial locoregional tumor control and survival data. The local control and disease-free survival rates in the combined modality group are significantly superior at the p = 0.0006 and p = 0.0003 levels, respectively, relative to the group treated with surgery alone. Patients in the combined modality group also experienced a significantly improved adjusted and overall survival, p = 0.005 and p = 0.01, respectively. The administration of postoperative irradiation was not associated with an increased rate of complications. The benefit of radiotherapy on survival was only seen when given as postoperative treatment but was lost in patients treated for salvage after tumor recurrence. |
| Databáze: | OpenAIRE |
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