Biological Markers Associated with Prolonged Survival in African Children Maternally Infected by the Human Immunodeficiency Virus Type 1
| Autor: | Claude Desgranges, Andrea Kleinschmidt, Françoise Bex, Arlette Simonon, Frances Gotch, Arsène Burny, Philippe Lepage, Volker Erfle, Christiaan Van Goethem, Kristina Broliden, Anatholie Bazubagira, Philippe Van de Perre, D.G. Hitimana |
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| Rok vydání: | 1992 |
| Předmět: |
Cytotoxicity
Immunologic Blotting Western Immunology Population HIV Infections HIV Antibodies Major histocompatibility complex Virus Immune system Neutralization Tests Virology Immunopathology Humans Cytotoxic T cell Medicine Child education education.field_of_study biology business.industry Antibody-Dependent Cell Cytotoxicity Rwanda Survival Analysis Infectious Diseases Child Preschool HIV-1 biology.protein Viral disease Antibody business Biomarkers T-Lymphocytes Cytotoxic |
| Zdroj: | AIDS Research and Human Retroviruses. 8:435-442 |
| ISSN: | 1931-8405 0889-2229 |
| DOI: | 10.1089/aid.1992.8.435 |
| Popis: | Sixteen children over the age of 5 years (Group 1) have been identified out of 537 children infected by human immunodeficiency virus and born to HIV-infected mothers, in Kigali, Rwanda. They were followed up for 2 years and compared with 16 younger AIDS patients (Group 2) and with 16 age- and gender-matched HIV-1 seronegative children (Group 3). Fourteen Group 1 subjects had anti-HIV-1 IgM which persisted during the entire study period, in 11 cases directed to HIV-1 envelope proteins. In vitro, immortalization of B lymphocytes by the Epstein-Barr virus confirmed a high production of IgM to envelope proteins. All these patients had anti-p 17 IgG which was not observed in 7 patients from Group 2. All 16 children mounted significant titers of neutralizing antibodies to HTLV-IIIB, and, in 8 patients tested, against two other HIV-1 strains, RII and MN. HIV-1-specific major histocompatibility complex (MHC)-restricted cytotoxic T cells were demonstrated in 3 of 5 of the subgroup who were tested. Prolonged survival over 5 years in children with maternally acquired HIV-1 infection is associated with a high titer of neutralizing antibodies, a persistent production of IGM to HIV-1 envelope proteins and of IgG to p 17. |
| Databáze: | OpenAIRE |
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