Local α-Tocopherol for Acute and Short-Term Vaginal Toxicity Prevention in Patients Treated With Radiotherapy for Gynecologic Tumors
| Autor: | Martina Rossi, Anna Myriam Perrone, Serena Medoro, Mariangela La Macchia, Donatella Santini, Pierandrea De Iaco, Lucia Ricci Maccarini, F. Pozzati, Isabella Strada, Andrea Galuppi |
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| Přispěvatelé: | Galuppi A., Perrone A.M., La Macchia M., Santini D., Medoro S., Maccarini L.R., Strada I., Pozzati F., Rossi M., De Iaco P. |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Administration Topical medicine.medical_treatment Vaginal Diseases alpha-Tocopherol Uterine Cervical Neoplasms Acanthosis Gastroenterology Antioxidants Endometrial cancer Internal medicine Humans Medicine Radiation Injuries Adverse effect Aged Cervical cancer Radiotherapy business.industry Vaginal toxicity α-Tocopherol acetate Obstetrics and Gynecology medicine.disease Endometrial Neoplasms Clinical trial Radiation therapy medicine.anatomical_structure Oncology Vagina Toxicity Female business Adjuvant |
| Zdroj: | International Journal of Gynecologic Cancer. 21:1708-1711 |
| ISSN: | 1525-1438 1048-891X |
| DOI: | 10.1097/igc.0b013e318223659d |
| Popis: | IntroductionData in literature about the use of adjuvant treatment to reduce acute adverse effects of radiotherapy on the pelvis are scant, with the exception of a few reports on the topical use of estrogen, which promotes proliferation of epithelium.Materials and MethodsIn this prospective trial, α-tocopherol acetate was topically administered to patients affected by endometrial and cervical cancer and undergoing radiation treatment to avoid acute vaginal complications.ResultsVaginal application of α-tocopherol reduced vaginal toxicity and pain, although vaginal secretion was not significantly different in the 2 groups studied. The histological scoring system showed a significant reduction of inflammation, no difference in fibrosis, and an increase of acanthosis.ConclusionsThe use of α-tocopherol as adjuvant treatment to reduce the acute adverse effects of radiotherapy on the vagina should be considered. |
| Databáze: | OpenAIRE |
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