Epigenetic modification and a role for the E3 ligase RNF40 in cancer development and metastasis
| Autor: | Jae-Hoon Kim, Kyathegowdanadoddi Srinivasa Balaji, Li Liao, Jiangzhou Peng, Junjiang Fu, Chunli Wei |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research Ubiquitin-Protein Ligases Review Article Computational biology Gene Expression Regulation Enzymologic Epigenesis Genetic law.invention Metastasis 03 medical and health sciences 0302 clinical medicine law Neoplasms Genetics medicine Ring finger Histone H2B Humans Epigenetics Neoplasm Metastasis Cancer genetics Molecular Biology Gene Oncogene biology medicine.disease Neoplasm Proteins Ubiquitin ligase Gene Expression Regulation Neoplastic 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis biology.protein Suppressor |
| Zdroj: | Oncogene |
| ISSN: | 1476-5594 0950-9232 |
| Popis: | RNF40 (OMIM: 607700) is a really interesting new gene (RING) finger E3 ubiquitin ligase containing multiple coiled-coil domains and a C-terminal RING finger motif, which engage in protein–DNA and protein–protein interactions. RNF40 encodes a polypeptide of 1001 amino acids with a predicted molecular mass of 113,678 Da. RNF40 and its paralog RNF20 form a stable heterodimer complex that can monoubiquitylate histone H2B at lysine 120 as well as other nonhistone proteins. Cancer is a major public health problem and the second leading cause of death. Through its protein ubiquitylation activity, RNF40 acts as a tumor suppressor or oncogene to play major epigenetic roles in cancer development, progression, and metastasis, highlighting the essential function of RNF40 and the importance of studying it. In this review, we summarize current knowledge about RNF40 gene structure and the role of RNF40 in histone H2B monoubiquitylation, DNA damage repair, apoptosis, cancer development, and metastasis. We also underscore challenges in applying this information to cancer prognosis and prevention and highlight the urgent need for additional investigations of RNF40 as a potential target for cancer therapeutics. |
| Databáze: | OpenAIRE |
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