Relationship between postoperative recurrence and expression of cyclin E, p27, and Ki-67 in non-small cell lung cancer without lymph node metastases
| Autor: | Yoshitsugu Yamada, Ryou Hatanaka, Yoshimasa Kamata, Wakako Tamo, Takahashi S, Takao Tsushima, Ikuo Fukuda, Masashi Koyanagi, Shunichi Takaya |
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| Rok vydání: | 2002 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Cyclin E Lung Neoplasms Adenocarcinoma Disease-Free Survival Recurrence Internal medicine Carcinoma Non-Small-Cell Lung Proliferating Cell Nuclear Antigen medicine Biomarkers Tumor Humans Lung cancer Lymph node Survival rate Cyclin Aged Aged 80 and over biology business.industry Hematology General Medicine Middle Aged medicine.disease Prognosis Immunohistochemistry medicine.anatomical_structure Ki-67 Antigen Ki-67 Lymphatic Metastasis Multivariate Analysis biology.protein Carcinoma Squamous Cell Surgery Female business |
| Zdroj: | International journal of clinical oncology. 7(6) |
| ISSN: | 1341-9625 |
| Popis: | Background: Cyclin E and p27 play pivotal roles in cancer development and progression. We investigated whether the prognosis in cases of non-small cell lung cancer without lymph node metastases that underwent complete resection could be associated with tissue expression of cyclin E, p27, and Ki-67. Methods: Tumors from 62 patients at least 5 years after surgery were assessed by immunohistochemistry for expression of cyclin E, p27, and Ki-67. Disease-free survival (DFS) after surgery was used to evaluate disease prognosis. We also investigated the relationship between expression of these factors and postoperative recurrence. Results: In non-small cell lung cancer, p27-negative expression and pT factor were significantly unfavorable prognostic factors in multivariate analysis. The DFS rate in cyclin E-positive expression was significantly lower than in cyclin E-negative expression. Similarly, p27-negative expression and high Ki-67 expression correlated with a shortened DFS rate. In combinations of expression of cyclin E and p27, the cyclin E-negative/p27-positive group had a significantly higher DFS rate than did the other groups. According to histological type, there were correlations between the risk of postoperative recurrence and expression of these three biological factors, especially in adenocarcinoma. Conclusion: By analyzing the expression of cyclin E, p27, and Ki-67 of tumor cells, it was possible to extract the patient group for whom closer follow-up and postoperative treatment is necessary to improve survival rate. |
| Databáze: | OpenAIRE |
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